A Systematic Review of Clinical Diagnostic Systems Used in the Diagnosis of Tuberculosis in Children

Table 3

Studies evaluating and comparing multiple diagnostic systems.

Author	Year	Country	Findings
Hesseling et al. [21]	2002	South Africa	Analyzed 16 diagnostic systems, specifically looks at how systems have been adapted for HIV-infected and malnourished patients.
Edwards et al. [47]	2007	Congo	Analyzed 8 scoring systems, found correlation to be poor to moderate. Decision to initiate treatment for TB was dependent on scoring system used in 14% of children. Selection had a greater impact in HIV-infected patients.
Ahmed et al. [48]	2008	Bangladesh	Reviews previous scoring systems as well as Hesseling et al. [21] and Edwards et al. [47]
Raqib et al. [49]	2009	Bangladesh	Analyzed a new diagnostic test (ALS assay) detecting antibodies secreted from circulating MTB-specific plasma cells in comparison to the Kenneth Jones and WHO/Keith Edwards scoring criteria as well as clinical diagnosis.