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AIDS Research and Treatment
Volume 2012 (2012), Article ID 790786, 8 pages
Review Article

Challenges in the Management of HIV-Infected Malnourished Children in Sub-Saharan Africa

1Department of Paediatrics & Child Health, University of Malawi College of Medicine, Private Bag 360, Chichiri 3, Blantyre, Malawi
2Department of Pediatrics, Washington University in St. Louis, Campus Box 8116, One Children’s Place, St. Louis, MO 63110, USA

Received 15 September 2011; Revised 16 November 2011; Accepted 17 November 2011

Academic Editor: Anthony Harries

Copyright © 2012 Indi Trehan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Infection with HIV, and oftentimes coinfection with TB, complicates the care of severely malnourished children in sub-Saharan Africa. These superimposed infections challenge clinicians faced with a population of malnourished children for whose care evidence-based guidelines have not kept up. Even as the care of HIV-uninfected malnourished children has improved dramatically with the advent of community-based care and even as there are hopeful signs that the HIV epidemic may be stabilizing or ameliorating, significant gaps remain in the care of malnourished children with HIV. Here we summarize what is currently known, what remains unknown, and what remains challenging about how to treat severely malnourished children with HIV and TB.