Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana
Table 2
Immunological, haematological, and biochemical profiles of the study population stratified by HAART status.
Parameter
Total ()
On-HAART ()
HAART-naive ()
value
Immunological profile (mean ± SD)
CD4 (cells/mm3)
426.40 ± 191.40
475.40 ± 229.50
207.10 ± 102.20
<0.0001
CD3 (cells/mm3)
1329.00 ± 513.70
1394.00 ± 403.9
1036.00 ± 377.2
0.0007
CD4/CD3
0.31 ± 0.12
0.34 ± 0.12
0.20 ± 0.56
<0.0001
WBC (103/μL)
5.23 ± 1.86
5.09 ± 1.81
5.88 ± 1.70
0.0151
Haematological profile (mean ± SD)
Hb (g/dL)
11.65 ± 1.70
11.89 ± 1.56
10.59 ± 1.88
<0.0001
RBC (106/μL)
3.86 ± 0.58
3.84 ± 0.58
3.93 ± 0.62
0.3576
HCT (%)
35.01 ± 4.76
35.67 ± 4.41
32.04 ± 5.18
<0.0001
MCV (fL)
91.82 ± 11.73
97.99 ± 10.96
82.09 ± 10.08
<0.0001
MCH (pg)
31.79 ± 5.14
32.67 ± 4.97
27.87 ± 3.98
<0.0001
MCHC (g/dL)
34.62 ± 2.83
34.75 ± 2.78
34.03 ± 2.99
0.1433
RDW-CV
15.17 ± 1.76
14.96 ± 1.57
16.13 ± 2.25
0.0001
RDW-SD
52.20 ± 7.28
52.82 ± 7.41
49.40 ± 5.99
0.0068
PLT (103/μL)
242.3 ± 78.75
240.50 ± 71.32
250.40 ± 106.60
0.4756
Biochemical profile (mean ± SD)
Iron (μmol/L)
13.63 ± 11.73
14.51 ± 12.40
9.70 ± 3.94
0.0187
Ferritin (μg/L)
255.00 ± 51.48
265.20 ± 89.96
238.10 ± 57.45
0.0691
Transferrin (mg/dL)
203.90 ± 36.81
199.60 ± 30.28
223.20 ± 54.05
0.0002
TIBC (μg/dL)
259.00 ± 46.75
253.50 ± 38.45
283.50 ± 68.64
0.0002
% TSAT
30.82 ± 27.08
33.00 ± 18.57
21.06 ± 10.85
0.0114
Data are presented as mean ± SD. values represent comparisons between On-HAART and HAART-naïve participants. values < 0.05 were considered significant. WBC = White Blood Cells, Hb = haemoglobin, RBC = Red Blood Cells, HCT = haematocrit, MCV = Mean Cell Volume, MCH = Mean Cell Haemoglobin, MCHC = Mean Cell Haemoglobin Concentration, RDW-CV = Red Cell Distribution Width-Cumulative Variance, RDW-SD = Red Cell Distribution Width-Standard Deviation, PLT = platelets, TIBC = Total Iron Binding Capacity, TSAT = transferrin saturation, and HAART = Highly Active Antiretroviral Therapy.
