Anaemia and Iron Homeostasis in a Cohort of HIV-Infected Patients: A Cross-Sectional Study in Ghana
Table 6
Immunological, haematological, and biochemical profiles of the population under study stratified by iron status.
Parameter
Anaemia ()
Iron deficiency ()
Iron deficiency anaemia ()
Iron overload ()
value
value (trend)
Age
36.87 ± 11.25
38.23 ± 11.41
36.22 ± 10.37
38.85 ± 6.52
0.8002
0.7059
CD4 (cells/mm3)
264.50 ± 84.00
322.20 ± 102.80
233.10 ± 103.2
429.50 ± 124.1
0.211
0.1693
CD3 (cells/mm3)
1029.00 ± 425.20
1154.00 ± 401.00
1021.00 ± 426.1
1478.00 ± 452.10
0.1263
0.0519
CD4/CD3
0.23 ± 0.07
0.25 ± 0.07
0.19 ± 0.04
0.29 ± 0.09
0.2379
0.4632
WBC (103/μL)
5.06 ± 2.00
5.31 ± 0.29
5.57 ± 1.39
4.72 ± 1.20
0.6036
0.7046
Haematological profile
Hb (g/dL)
9.32 ± 1.17
10.73 ± 2.19
8.89 ± 1.35
11.75 ± 1.11
<0.0001
0.0008
RBC (106/μL)
3.43 ± 0.52
3.86 ± 0.72
3.45 ± 0.56
3.79 ± 0.58
0.0016
0.2581
HCT (%)
28.89 ± 3.56
32.66 ± 6.13
27.60 ± 3.80
34.29 ± 3.46
<0.0001
0.0155
MCV (fL)
85.41 ± 12.13
85.70 ± 12.80
81.35 ± 12.36
92.12 ± 14.50
0.0954
0.1948
MCH (pg)
28.39 ± 5.30
29.18 ± 5.39
27.18 ± 5.54
31.72 ± 4.96
0.0785
0.1214
MCHC (g/dL)
33.24 ± 3.21
34.05 ± 3.04
33.36 ± 3.37
34.51 ± 1.15
0.3722
0.2879
RDW-CV
16.61 ± 2.16
15.76 ± 2.18
16.76 ± 2.08
14.98 ± 1.47
0.0161
0.0579
RDW-SD
52.59 ± 8.49
50.98 ± 6.86
50.66 ± 7.52
51.02 ± 7.05
0.6319
0.4892
PLT (103/μL)
251.50 ± 91.12
252.80 ± 95.10
270.60 ± 88.36
220.30 ± 97.97
0.461
0.3957
Biochemical profile
Iron (μmol/L)
8.93 ± 2.98
4.60 ± 1.82
4.01 ± 2.07
49.47 ± 19.94
<0.0001
<0.0001
Ferritin (μg/L)
229.00 ± 55.13
223.80 ± 53.00
248.90 ± 62.32
193.10 ± 16.69
0.0215
0.1106
Transferrin (mg/dL)
290.80 ± 70.02
284.20 ± 67.31
316.10 ± 79.14
245.20 ± 21.20
0.0215
0.1106
TIBC (μg/dL)
18.87 ± 7.49
9.60 ± 2.96
7.71 ± 2.24
112.80 ± 47.94
<0.0001
<0.0001
values < 0.05 were considered significant. values represent one-way ANOVA of all variables. WBC = White Blood Cells, Hb = haemoglobin, RBC = Red Blood Cells, HCT = haematocrit, MCV = Mean Cell Volume, MCH = Mean Cell Haemoglobin, MCHC = Mean Cell Haemoglobin Concentration, RDW-CV = Red Cell Distribution Width-Cumulative Variance, RDW-SD = Red Cell Distribution Width-Standard Deviation, PLT = platelets, TIBC = Total Iron Binding Capacity, TSAT = transferrin saturation, and HAART = Highly Active Antiretroviral Therapy.
