Trends and Adaptive Optimal Set Points of CD4⁺ Count Clinical Covariates at Each Phase of the HIV Disease Progression

Table 2

Significance of the CD4⁺ count clinical covariates in the fitted GAMM.

	Intercept,		Estimate	Std. error	t value	Pr (>|t|)
			574.3461	23.6848	24.2496	<0.001
	Smoothed trends
	Overall,	M-1	M-index	edf	F	value
1	s(red blood cells)	4	0.97	0.0005	0.0001	0.2407
2	s(haematocrit)	4	0.88	2.3867	1.4682	0.0002
3	s(MCV)	4	0.98	3.4599	10.9677	0.0001
4	s(MCHC)	4	0.96	0.0005	0.0001	0.3866
5	s(platelet)	4	0.99	3.1121	7.0860	0.0001
6	s(lymphocytes)	4	0.98	3.9278	89.0726	0.0001
7	s(monocytes)	4	0.98	2.8098	6.8695	0.0001
8	s(basophils)	4	0.80	3.2409	5.1025	0.0001
9	s(ALP)	4	0.95	1.8215	1.2221	0.0010
10	s(calcium)	4	0.83	0.0002	0.0000	0.7152
11	s(magnesium)	4	0.80	0.0001	0.0000	0.7418
12	s(potassium)	4	0.94	0.0014	0.0003	0.3348
13	s(sodium)	4	0.89	1.8233	1.4124	0.0022
14	s(total protein)	4	0.89	3.6558	16.7466	0.0001
15	s(albumin)	4	0.86	3.3584	8.5429	0.0001
16	s(LDH)	4	0.91	0.0056	0.0014	0.0167
17	s(folate)	4	0.79	3.4563	18.2167	0.0001
	Phase specific,
1	s(red blood cells, phase)	20	0.97	5.7216	0.5062	0.0232
2	s(haematocrit, phase)	20	0.88	6.8664	0.8138	0.0008
3	s(MCV, phase)	20	0.98	0.0006	0.0000	0.3808
4	s(MCHC, phase)	20	0.96	2.7234	0.1963	0.1484
5	s(platelet, phase)	20	0.99	4.0657	0.4305	0.0205
6	s(lymphocytes, phase)	20	0.98	6.4017	1.1305	0.0001
7	s(monocytes, phase)	20	0.98	1.2916	0.0823	0.2127
8	s(basophils, phase)	20	0.80	0.0011	0.0000	0.4206
9	s(ALP, phase)	20	0.95	5.1570	0.6649	0.0022
10	s(calcium, phase)	20	0.83	0.9796	0.0587	0.2741
11	s(magnesium, phase)	20	0.80	0.0011	0.0001	0.4274
12	s(potassium, phase)	20	0.94	0.0003	0.0000	0.6605
13	s(sodium, phase)	20	0.89	3.0043	0.2508	0.0652^†
14	s(total protein, phase)	20	0.89	3.9438	0.4838	0.0099
15	s(albumin, phase)	20	0.86	4.0936	0.3857	0.0381
16	s(LDH, phase)	20	0.91	10.1688	1.6168	0.0001
17	s(folate, phase)	20	0.79	0.0003	0.0000	0.7075

Bold represents significance at 5% level. ^†Significant at 10% level.