Rationale for Targeting CD6 as a Treatment for Autoimmune Diseases

Table 2

Anti-CD6 SRCR-D1 mAbs and functional effects.

Clone	Functional response	Cross-link	Author
BLTP6a, UMCD6 and MT502	Block T-cell Ag dependant activation	No	[18]
161.8	Induces Erk1/2 activation	Yes	[37]
IorT1, 2H1, T12, 6D3, Dako-CD6	Enhance anti-CD3, anti-CD28 and PMA T cell proliferation	Yes	[70, 71]
Ior T1	Protects B-CLL from anti-IgM apoptosis	Yes	[25]
UMCD6	Blocks T-cell/keratinocyte interaction	No	[18]