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Volume 2012 (2012), Article ID 176298, 6 pages
Review Article

Psoriatic Arthritis: An Update

1Department of Internal Medicine, University of Chicago (NorthShore), 2650 Ridge Avenue, Evanston, IL 60201, USA
2Department of Dermatology, Baylor University Medical Center, Dallas, TX 75246, USA

Received 3 August 2012; Accepted 13 October 2012

Academic Editor: Shigeru Kotake

Copyright © 2012 Peter Lloyd et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Psoriatic arthritis is a debilitating condition, which affects approximately one-quarter of psoriasis patients. Recent findings have furthered our understanding of the complex pathophysiology of PsA. There have been major advances in the identification of genes associated with joint involvement but not with cutaneous disease alone. The elucidation of key immunologic pathways has allowed the development of novel targeted therapies that are in the research pipeline. Currently, good screening tests and biomarkers to diagnose early PsA and to guide therapy are limited. In this paper, we present recent findings with regard to the immunopathogenesis and genetics of PsA, biomarkers, and screening tools and review the targeted therapies currently in clinical trials.