Table 1: Characteristics and effects of silicon-derived compounds.

Biological EffectSilicaAsbestosSiliconeNanoparticles

SourcesConstruction, MinningConstruction, MinningBreast implants Nanotecnology, Drug delivery

InflammationNALP3 InflammationNALP3 InflammationNo testedNALP3 Inflammation
Release of proinflammatory cytokines (IL-1β, IL-8, TNFα, IL-6)Release of proinflammatory cytokines (IL-1β, IL-8, IFNγ)Release of proinflammatory cytokines (IL-1, IL-2)Release of proinflammatory cytokines (IL-1β, TNFα, IL-6, IFNγ)

SerologyProduction of Autoantibodies (ANAs, ENAs, RF, Anti-Fas, Anti-CCP)Production of Autoantibodies (ANAs, AFAs)Production of Autoantibodies (ANAs)Production of Autoantibodies (anti-CCP)

Cellular responsesROS productionROS productionNo testedROS production
Apoptosis ApoptosisApoptosis

Tissue FibrosisTissue FibrosisTissue FibrosisTissue Fibrosis
OutcomePerpetuation of the responses along the time
Rheumatoid Arthritis