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Arthritis
Volume 2013 (2013), Article ID 461486, 14 pages
http://dx.doi.org/10.1155/2013/461486
Clinical Study

Differences in Mammalian Target of Rapamycin Gene Expression in the Peripheral Blood and Articular Cartilages of Osteoarthritic Patients and Disease Activity

1Clinical Immunology Department, Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow 115522, Russia
2Department of Surgery, McGill University, Montreal, QC, Canada H3A OG4
3Osteoarthritis Laboratory, Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow 115522, Russia
4Pathomorphology Department, Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow 115522, Russia
5Statistics Department, Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow 115522, Russia
6Forensic Medicine Service, Moscow City Health Department, Moscow 111020, Russia
7Surgery Department, Research Institute of Rheumatology, Russian Academy of Medical Sciences, Moscow 115522, Russia

Received 28 February 2013; Revised 12 May 2013; Accepted 12 May 2013

Academic Editor: Ruben Burgos-Vargas

Copyright © 2013 Elena V. Tchetina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [10 citations]

The following is the list of published articles that have cited the current article.

  • Elena V. Tchetina, Natalia V. Demidova, Dmitry E. Karateev, and Eugeny L. Nasonov, “Rheumatoid Factor Positivity Is Associated with Increased Joint Destruction and Upregulation of Matrix Metalloproteinase 9 and Cathepsin K Gene Expression in the Peripheral Blood in Rheumatoid Arthritic Patients Treated with Methotrexate,” International Journal of Rheumatology, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Jy He Jie-Yu, “mTOR Signaling in Aging and Aging-associated Diseases,” Progress in Biochemistry and Biophysics, vol. 41, no. 3, pp. 257–265, 2014. View at Publisher · View at Google Scholar
  • Xiaohong Wang, Heinz C. Schröder, and Werner E. G. Müller, “Polyphosphate as a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications,” Biotechnology Journal, 2015. View at Publisher · View at Google Scholar
  • Bandna Pal, Helal Endisha, Yue Zhang, and Mohit Kapoor, “mTOR: A Potential Therapeutic Target in Osteoarthritis?,” Drugs in R&D, 2015. View at Publisher · View at Google Scholar
  • Yu-Sheng Li, Fang-Jie Zhang, Chao Zeng, Wei Luo, Wen-Feng Xiao, Shu-Guang Gao, and Guang-Hua Lei, “Autophagy in osteoarthritis,” Joint Bone Spine, 2015. View at Publisher · View at Google Scholar
  • Mukundan Attur, Svetlana Krasnokutsky, Alexander Statnikov, Jonathan Samuels, Zhiguo Li, Olga Friese, Marie-Pierre Hellio Le Graverand-Gastineau, Leon Rybak, Virginia B. Kraus, Joanne M. Jordan, Constantin F. Aliferis, and Steven B. Abramson, “Low-Grade Inflammation in Symptomatic Knee Osteoarthritis: Prognostic Value of Inflammatory Plasma Lipids and Peripheral Blood Leukocyte Biomarkers,” Arthritis & Rheumatology, vol. 67, no. 11, pp. 2905–2915, 2015. View at Publisher · View at Google Scholar
  • Elena V. Tchetina, Karina A. Maslova, Mikhail Y. Krylov, and Valery A. Myakotkin, “Association of Bone Loss with the Upregulation of Survival-Related Genes and Concomitant Downregulation of Mammalian Target of Rapamycin and Osteoblast Differentiation-Related Genes in the Peripheral Blood of Late Postmenopausal Osteoporotic Women,” Journal of Osteoporosis, vol. 2015, pp. 1–8, 2015. View at Publisher · View at Google Scholar
  • Daniel J Klionsky, Kotb Abdelmohsen, Akihisa Abe, Md Joynal Abedin, Hagai Abeliovich, Abraham Acevedo Arozena, Hiroaki Adachi, Christopher M Adams, Peter D Adams, Khosrow Adeli, Peter J Adhihetty, Sharon G Adler, Galila Agam, Rajesh Agarwal, Manish K Aghi, Maria Agnello, Patrizia Agostinis, Patricia V Aguilar, Julio Aguirre-Ghiso, Edoardo M Airoldi, Slimane Ait-Si-Ali, Takahiko Akematsu, Emmanuel T Akporiaye, Mohamed Al-Rubeai, Guillermo M Albaiceta, Chris Albanese, Diego Albani, Matthew L Albert, Jesus Aldudo, Hana Algül, Mehrdad Alirezaei, Iraide Alloza, Alexandru Almasan, Maylin Almonte-Beceril, Emad S Alnemri, Covadonga Alonso, Nihal Altan-Bonnet, Dario C Altieri, Silvia Alvarez, Lydia Alvarez-Erviti, Sandro Alves, Giuseppina Amadoro, Atsuo Amano, Consuelo Amantini, Santiago Ambrosio, Ivano Amelio, Amal O Amer, Mohamed Amessou, Angelika Amon, Zhenyi An, Frank A Anania, Stig U Andersen, Usha P Andley, Catherine K Andreadi, Nathalie Andrieu-Abadie, Alberto Anel, David K Ann, Shailendra Anoopkumar-Dukie, Manuela Antonioli, Hiroshi Aoki, Nadezda Apostolova, Saveria Aquila, Katia Aquilano, Koichi Araki, Eli Arama, Agustin Aranda, Jun Araya, Alexandre Arcaro, Esperanza Arias, Hirokazu Arimoto, Aileen R Ariosa, Jane L Armstrong, Thierry Arnould, Ivica Arsov, Katsuhiko Asanuma, Valerie Askanas, Eric Asselin, Ryuichiro Atarashi, Sally S Atherton, Julie D Atkin, Laura D Attardi, Patrick Auberger, Georg Auburger, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Maria Laura Avantaggiati, Limor Avrahami, Suresh Awale, Neelam Azad, Tiziana Bachetti, Jonathan M Backer, Dong-Hun Bae, Jae-sung Bae, Ok-Nam Bae, Soo Han Bae, Eric H Baehrecke, Seung-Hoon Baek, Stephen Baghdiguian, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xue-Yuan Bai, Yannick Bailly, Kithiganahalli Narayanaswamy Balaji, Walter Balduini, Andrea Ballabio, Rena Balzan, Rajkumar Banerjee, Gábor Bánhegyi, Haijun Bao, Benoit Barbeau, Maria D Barrachina, Esther Barreiro, Bonnie Bartel, Alberto Bartolomé, Diane C Bassham, Maria Teresa Bassi, Robert C Bast, Alakananda Basu, Maria Teresa Batista, Henri Batoko, Maurizio Battino, Kyle Bauckman, Bradley L Baumgarner, K Ulrich Bayer, Rupert Beale, Jean-François Beaulieu, George R. Beck, Christoph Becker, J David Beckham, Pierre-André Bédard, Patrick J Bednarski, Thomas J Begley, Christian Behl, Christian Behrends, Georg MN Behrens, Kevin E Behrns, Eloy Bejarano, Amine Belaid, Francesca Belleudi, Giovanni Bénard, Guy Berchem, Daniele Bergamaschi, Matteo Bergami, Ben Berkhout, Laura Berliocchi, Amélie Bernard, Monique Bernard, Francesca Bernassola, Anne Bertolotti, Amanda S Bess, Sébastien Besteiro, Saverio Bettuzzi, Savita Bhalla, Shalmoli Bhattacharyya, Sujit K Bhutia, Caroline Biagosch, Michele Wolfe Bianchi, Martine Biard-Piechaczyk, Viktor Billes, Claudia Bincoletto, Baris Bingol, Sara W Bird, Marc Bitoun, Ivana Bjedov, Craig Blackstone, Lionel Blanc, Guillermo A Blanco, Heidi Kiil Blomhoff, Emilio Boada-Romero, Stefan Böckler, Marianne Boes, Kathleen Boesze-Battaglia, Lawrence H Boise, Alessandra Bolino, Andrea Boman, Paolo Bonaldo, Matteo Bordi, Jürgen Bosch, Luis M Botana, Joelle Botti, German Bou, Marina Bouché, Marion Bouchecareilh, Marie-Josée Boucher, Michael E Boulton, Sebastien G Bouret, Patricia Boya, Michaël Boyer-Guittaut, Peter V Bozhkov, Nathan Brady, Vania MM Braga, Claudio Brancolini, Gerhard H Braus, José M Bravo-San Pedro, Lisa A Brennan, Emery H Bresnick, Patrick Brest, Dave Bridges, Marie-Agnès Bringer, Marisa Brini, Glauber C Brito, Bertha Brodin, Paul S Brookes, Eric J Brown, Karen Brown, Hal E Broxmeyer, Alain Bruhat, Patricia Chakur Brum, John H Brumell, Nicola Brunetti-Pierri, Robert J Bryson-Richardson, Shilpa Buch, Alastair M Buchan, Hikmet Budak, Dmitry V Bulavin, Scott J Bultman, Geert Bultynck, Vladimir Bumbasirevic, Yan Burelle, Robert E Burke, Margit Burmeister, Peter Bütikofer, Laura Caberlotto, Ken Cadwel View at Publisher · View at Google Scholar
  • Elena V. Tchetina, Galina A. Markova, A. Robin Poole, David J. Zukor, John Antoniou, Sergey A. Makarov, and Aleksandr N. Kuzin, “Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage,” International Journal of Rheumatology, vol. 2016, pp. 1–14, 2016. View at Publisher · View at Google Scholar
  • Elena V. Tchetina, Anastasya N. Pivanova, Galina A. Markova, Galina V. Lukina, Elena N. Aleksandrova, Andrey P. Aleksankin, Sergey A. Makarov, and Aleksandr N. Kuzin, “Rituximab Downregulates Gene Expression Associated with Cell Proliferation, Survival, and Proteolysis in the Peripheral Blood from Rheumatoid Arthritis Patients: A Link between High Baseline Autophagy-Related ULK1 Expression and Improved Pain Control,” Arthritis, vol. 2016, pp. 1–12, 2016. View at Publisher · View at Google Scholar