Table 2: Statistically significant associations in group with early knee OA (grade = 1) with ADAM12 gene SNPs (were observed only for rs1044122).
Grade 0
Grade 1
OR (95% CI)
P value
Corrected P value**
Rs1044122, whole group
OA in TFJ
A allele
61%
68%
1.37 (1.01–1.87)
0.042
0.087
AA
82 (39%)
79 (43%)
2.43 (1.17–5.05)
0.017
0.036
AG
93 (45%)
92 (50%)
3.26 (1.10–4.62)
0.026
0.054
GG
34 (16%)
14 (7%)
1*
1*
Rs1044122, females
OA in TFJ
A allele
60%
70%
1.63 (1.12–2.37)
0.018
0.038
AA
53 (37%)
58 (44%)
3.78 (1.5–9.54)
0.005
0.010
AG
66 (46%)
65 (50%)
2.92 (1.18–7.23)
0.021
0.043
GG
24 (17%)
8 (6%)
1*
1*
Rs1044122, females
OPH in TFJ
A allele
60%
70%
1.57 (1.08–2.29)
0.018
0.038
AA
61 (37%)
50 (45%)
3.81 (1.42–10.23)
0.008
0.017
AG
76 (47%)
56 (50%)
3.09 (1.17–8.16)
0.023
0.048
GG
26 (16%)
6 (5%)
1*
1*
OA in TFJ: radiographic osteoarthritis in tibiofemoral joint; OPH in TFJ: osteophytes in tibiofemoral joint; GG genotypes were analysed as base; for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.