Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

Table 2

Statistically significant associations in group with early knee OA (grade = 1) with ADAM12 gene SNPs (were observed only for rs1044122).


	Grade 0	Grade 1	OR (95% CI)	P value	Corrected P value**

Rs1044122, whole group	OA in TFJ

A allele	61%	68%	1.37 (1.01–1.87)	0.042	0.087
AA	82 (39%)	79 (43%)	2.43 (1.17–5.05)	0.017	0.036
AG	93 (45%)	92 (50%)	3.26 (1.10–4.62)	0.026	0.054
GG	34 (16%)	14 (7%)	1*	1*

Rs1044122, females	OA in TFJ

A allele	60%	70%	1.63 (1.12–2.37)	0.018	0.038
AA	53 (37%)	58 (44%)	3.78 (1.5–9.54)	0.005	0.010
AG	66 (46%)	65 (50%)	2.92 (1.18–7.23)	0.021	0.043
GG	24 (17%)	8 (6%)	1*	1*

Rs1044122, females	OPH in TFJ

A allele	60%	70%	1.57 (1.08–2.29)	0.018	0.038
AA	61 (37%)	50 (45%)	3.81 (1.42–10.23)	0.008	0.017
AG	76 (47%)	56 (50%)	3.09 (1.17–8.16)	0.023	0.048
GG	26 (16%)	6 (5%)	1*	1*

OA in TFJ: radiographic osteoarthritis in tibiofemoral joint; OPH in TFJ: osteophytes in tibiofemoral joint; GG genotypes were analysed as base; for multiple comparison correction Benjamini and Yekutieli method was used; in bold are shown statistically significant P values.

Arthritis

Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

Table 2