Treatment of Nongout Joint Deposition Diseases: An Update

Table 1

Therapeutic options for CPPD and BCP deposition diseases compared to those available in gout.

	Gout	CPPD	BCP
Guidelines	ACR (2012); EULAR (2006); BSR (2007)	EULAR (2011)	None
Local treatment of the flare	Intra-articular corticosteroid injection	Intra-articular corticosteroid injection	Periarticular corticosteroid injection-calcification aspiration-shockwave therapy
Efficacy of colchicine in flares	Yes	Yes	Limited data
Loading dose of colchicine	Yes	No	—
Efficacy of NSAIDs in flares	Yes	Yes	Yes
Efficacy of systemic corticosteroids in flares	Yes	Yes	Limited data
First-line preventive treatments	Xanthine oxydase inhibitors	None	None
Second-line preventive treatment	Uricosurics	Little data on colchicine	—
Third-line preventive treatment	Recombinant uricase	Little data on methotrexate and hydroxychloroquine	—
Efficacy of anti-interleukine-1 treatments	Established	Possible	Possible

CPPD: calcium pyrophosphate deposition; BCP: basic calcium phosphate; ACR: american college of rheumatology; EULAR: European league against rheumatic diseases; BSR: British society for rheumatology.