hemophil arthropathi progress disabl condit poor understood pathobiolog sinc emerg interest studi role intraarticular fat pad size biolog arthrit condit explor fat pad volum chang hemophil arthropathi what extent differ from osteoarthr match cohort 13 adult patient hemophil arthropathi knee age gendermatch cohort without osteoarthr control cohort same degre radiograph osteoarthr cohort 1 2 fashion infrapatellar fat pad ipfp suprapatellar fat pad spfp volum were calcul base magnet reson imag differ fat pad volum demograph height weight osteoarthr score were evalu fat pad volum were posit associ bodi size paramet all three cohort were unaffect degre osteoarthr while ipfp volum did differ between cohort spfp volum expand disproport weight hemophilia patient our observ indic ipfps spfps behav biolog differ respons differ arthrit stimuli the exagger expans spfp hemophilia patient highlight import further studi implic fat pad biolog progress hemophil arthropathi

Annette von Drygalski

Katherine C. Rappazzo

Richard F. W. Barnes

Eric Y. Chang

Knee Fat Pad Volumes in Patients with Hemophilia and Their Relationship with Osteoarthritis

larg anim model osteoarthr necessari test ground fda approv human medicin applic sheep model have advantag over other avail larg anim develop progress osteoarthr sheep exceed slow which handicap progress develop potenti treatment combin obliqu angl forc exercis increas stress stifl surgic destabil hasten develop osteoarthr ewe method earli detect clinic sign includ radiographi urin serum biomark assay gait analysi vivo use microcomput tomographi macroscop joint analysi our model abl produc clinic detect sign osteoarthr relat short period 14 week chang bone were high correl between microcomput tomographi radiograph analysi chang cartilag correl well between urinari glycosaminoglycan level serum aggrecanas analys exercis improv negat effect destabil bone exacerb negat effect destabil cartilag these observ suggest may need consid treatment bone cartilag separ these result repres improv larg anim model osteoarthr rapid onset diseas superior detect bone soft tissu chang

Rachel J. Hill

Holly M. Mason

Gavin Yeip

Samer S. Merchant

Aaron L. Olsen

Rusty D. Stott

Arnaud J. Van Wettere

Eadric Bressel

Jeffrey B. Mason

The Influence of Oblique Angle Forced Exercise in Surgically Destabilized Stifle Joints Is Synergistic with Bone, but Antagonistic with Cartilage in an Ovine Model of Osteoarthritis

remiss inflamm has becom achiev goal inflammatori rheumatoid arthriti howev bone eros continu mani patient interleukin 27 regul immun bone cell balanc also suppress activ sever inflammatori cell type despit it promis challeng clinic translat il27 have been it partial effect vivo due abil modul plastic bone immun cell differenti examin potenti sever microrna mir candid enhanc effect il27 using differenti luciferas real time quantit pcr assay show il27 promot osteoblast differenti reduc express osteoblast inhibitori gene reduc osteoclast differenti result suggest potenti coordin tgf bmp smad jak stat pathway select mirna regul relat pathway examin whether effect il27 could augment therapeut applic mir29b mir21 augment il27 proosteogen while downregul osteoclastogen signal also work reduc inflammatori signal activ macrophag while mir21 mir20b work il27 reduc inflammatori gene express fibroblast cell appear sever mirna can util enhanc il27 impact modul osteogenesi reduc proinflammatori signal

Manoel Figueiredo Neto

Marxa L. Figueiredo

Combination of Interleukin-27 and MicroRNA for Enhancing Expression of Anti-Inflammatory and Proosteogenic Genes

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