Table of Contents
Advances in Toxicology
Volume 2014, Article ID 262895, 10 pages
http://dx.doi.org/10.1155/2014/262895
Research Article

Evaluating Systemic Toxicity in Rabbits after Acute Ocular Exposure to Irritant Chemicals

Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala 695 012, India

Received 9 September 2014; Revised 15 October 2014; Accepted 20 October 2014; Published 19 November 2014

Academic Editor: Kanji Yamasaki

Copyright © 2014 Reshma Sebastian Cherian and Mohanan Parayanthala Valappil. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. Y. C. Kim, B. Chiang, X. Wu, and M. R. Prausnitz, “Ocular delivery of macromolecules,” Journal of Controlled Release, vol. 190, pp. 72–181, 2014. View at Google Scholar
  2. C. Gray, “Systemic toxicity with topical ophthalmic medications in children,” Paediatric and Perinatal Drug Therapy, vol. 7, no. 1, pp. 23–29, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Salminen, “Review: systemic absorption of topically applied ocular drugs in humans,” Journal of Ocular Pharmacology, vol. 6, no. 3, pp. 243–249, 1990. View at Publisher · View at Google Scholar · View at Scopus
  4. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall, “Protein measurement with the Folin phenol reagent,” The Journal of Biological Chemistry, vol. 193, no. 1, pp. 265–275, 1951. View at Google Scholar · View at Scopus
  5. A. Okado-Matsumoto and I. Fridovich, “Subcellular distribution of superoxide dismutases (SOD) in rat liver. Cu,Zn-SOD in mitochondria,” Journal of Biological Chemistry, vol. 276, no. 42, pp. 38388–38393, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. M. S. Moron, J. W. Depierre, and B. Mannervik, “Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver,” Biochimica et Biophysica Acta, vol. 582, no. 1, pp. 67–78, 1979. View at Publisher · View at Google Scholar · View at Scopus
  7. C. E. Mize and R. G. Langdon, “Hepatic glutathione reductase: purification and general kinetic properties,” The Journal of Biological Chemistry, vol. 237, pp. 1589–1595, 1962. View at Google Scholar · View at Scopus
  8. J. T. Rotruck, A. L. Pope, H. E. Ganther, A. B. Swanson, D. G. Hafeman, and W. G. Hoekstra, “Selenium: biochemical role as a component of glatathione peroxidase,” Science, vol. 179, no. 4073, pp. 588–590, 1973. View at Publisher · View at Google Scholar · View at Scopus
  9. S. Marklund and G. Marklund, “Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase,” European Journal of Biochemistry, vol. 47, no. 3, pp. 469–474, 1974. View at Publisher · View at Google Scholar · View at Scopus
  10. X.-J. Yi, Y. Wang, and F.-S. X. Yu, “Corneal epithelial tight junctions and their response to lipopolysaccharide challenge,” Investigative Ophthalmology & Visual Science, vol. 41, no. 13, pp. 4093–4100, 2000. View at Google Scholar · View at Scopus
  11. K. Green, K. A. Bowman, and R. D. Elijah, “Dose-effect response of the rabbit eye to cetylpyridinium chloride,” Journal of Toxicology—Cutaneous and Ocular Toxicology, vol. 4, no. 1, pp. 13–26, 1985. View at Publisher · View at Google Scholar · View at Scopus
  12. Y. Takahashi, M. Koike, H. Honda et al., “Development of the short time exposure (STE) test: an in vitro eye irritation test using SIRC cells,” Toxicology In Vitro, vol. 22, no. 3, pp. 760–770, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. H. Spielmann, S. Kalweit, M. Liebsch et al., “Validation study of alternatives to the Draize eye irritation test in Germany: Cytotoxicity testing and HET-CAM test with 136 industrial chemicals,” Toxicology in Vitro, vol. 7, no. 4, pp. 505–510, 1993. View at Publisher · View at Google Scholar · View at Scopus
  14. D. M. Bagley, J. R. Gardner, G. Holland, R. W. Lewis, H. Vrijhof, and A. P. Walker, “Eye irritation: updated reference chemicals data bank,” Toxicology in Vitro, vol. 13, no. 3, pp. 505–510, 1999. View at Publisher · View at Google Scholar · View at Scopus
  15. J. H. Draize, G. Woodard, and H. O. Calvery, “Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes,” Journal of Pharmacology and Experimental Therapeutics, vol. 82, no. 3, pp. 377–390, 1944. View at Google Scholar
  16. M. Barza, “Factors affecting the intraocular penetration of antibiotics: the influence of route, inflammation, animal species and tissue pigmentation,” Scandinavian Journal of Infectious Diseases, vol. 10, no. 14, pp. 151–159, 1978. View at Google Scholar · View at Scopus
  17. J. R. Tisoncik, M. J. Korth, C. P. Simmons, J. Farrar, T. R. Martin, and M. G. Katze, “Into the eye of the cytokine storm,” Microbiology and Molecular Biology Reviews, vol. 76, no. 1, pp. 16–32, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Weng, R. R. Mohan, Q. Li, and S. E. Wilson, “IL-1 upregulates keratinocyte growth factor and hepatocyte growth factor mRNA and protein production by cultured stromal fibroblast cells: interleukin-1β expression in the cornea,” Cornea, vol. 16, no. 4, pp. 465–471, 1997. View at Google Scholar · View at Scopus
  19. B. Uttara, A. V. Singh, P. Zamboni, and R. T. Mahajan, “Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options,” Current Neuropharmacology, vol. 7, no. 1, pp. 65–74, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Sies, “Oxidative stress: oxidants and antioxidants,” Experimental Physiology, vol. 82, no. 2, pp. 291–295, 1997. View at Google Scholar · View at Scopus
  21. H. Yin, L. Xu, and N. A. Porter, “Free radical lipid peroxidation: mechanisms and analysis,” Chemical Reviews, vol. 111, no. 10, pp. 5944–5972, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Sastre, F. V. Palladro, and J. Vina, “Glutathione,” in Reactions, Processes, vol. 2 of The Handbook of Environmental Chemistry, pp. 91–108, Springer, 2005. View at Publisher · View at Google Scholar
  23. I. A. Abreu and D. E. Cabelli, “Superoxide dismutases-a review of the metal-associated mechanistic variations,” Biochimica et Biophysica Acta, vol. 1804, no. 2, pp. 263–274, 2010. View at Publisher · View at Google Scholar · View at Scopus