Influence of Different Doses of Levofloxacin on Antioxidant Defense Systems and Markers of Renal and Hepatic Dysfunctions in Rats

Table 1

Effect of levofloxacin treatments on plasma creatinine, urea, and bilirubin levels in rats.

Treatment	Creatinine (mg/dL)	Urea (mg/dL)	Bilirubin (mg/dL)
Control	0.72 ± 0.02	36 ± 0.82	0.24 ± 0.02
LFX-1	0.80 ± 0.01 (19%)^*	47 ± 0.5 (31%)^*	0.48 ± 0.03 (100%)^*
LFX-2	0.88 ± 0.03 (22%)^*	52 ± 1.29 (44%)^*	0.56 ± 0.03 (133%)^*
LFX-3	0.91 ± 0.00 (26%)^*	55 ± 0.58 (53%)^*	0.66 ± 0.03 (175%)^*

The values are means ± SD for five rats in each group. ^*Significantly different from the control < 0.05. Values in parenthesis represent percentage (%) of the increase.