Influence of Different Doses of Levofloxacin on Antioxidant Defense Systems and Markers of Renal and Hepatic Dysfunctions in Rats

Table 2

Effects of levofloxacin treatments on plasma alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities in rats.

Treatment	ALP (U/L)	ALT (U/L)	AST (U/L)
Control	187 ± 2.44	33 ± 3.30	60 ± 3.09
LFX-1	220.8 ± 2.56 (18%)^*	48 ± 4.92 (45%)^*	82 ± 1.25 (37%)^*
LFX-2	256 ± 4.34 (37%)^*	52 ± 2.28 (58%)^*	86 ± 1.50 (43%)^*
LFX-3	276 ± 2.51 (48%)^*	55 ± 2.879 (67%)^*	94 ± 2.7 (57%)^*

The values are means ± SD for five rats in each group. ^*Significantly different from the control < 0.05. Values in parenthesis represent percentage (%) of the increase.