Cytotoxicity Induced by Tetracyclines via Protein Photooxidation

Scheme 2

Strategy of experiment. The four assays chosen were (a) the relative rates of TCs photodegradation, (b) the relative phototoxicity of TCs to human keratinocytes, (c) the binding to model proteins (BSA and RNase A), and (d) the photoreaction with specific amino acids and the relative amount of photo oxidation.