Dramatic Increase in Cerebral Blood Flow following Soman Intoxication If Signs of Symptoms Can Be Seen
Table 3
Physiological parameters presented as percent of baseline value (100%) in control rats (), rats intoxicated with Soman not showing signs of poisoning (), and rats showing signs of poisoning (). Values represent mean ± SEM.
Parameter
Symptoms
−10 min
0 min
5 min
20 min
30 min
35 min
% MAP
Control
100 ± 0
87 ± 5.6
92 ± 3.5
90 ± 5.5
82 ± 7.0
83 ± 6.6
No signs
100 ± 0
91 ± 5.8
84 ± 8.8
78 ± 5.6
80 ± 3.6
78 ± 6.9
Signs
100 ± 0
98 ± 2.6
93 ± 1.9
109 ± 7.8
135 ± 7.3
130 ± 4.8
% RR
Control
100 ± 0
103 ± 2.5
103 ± 3.9
100 ± 2.1
103 ± 3.5
109 ± 3.4
No signs
100 ± 0
97 ± 6.6
101 ± 3.6
97 ± 7.4
86 ± 5.5
91 ± 4.5
Signs
100 ± 0
107 ± 3.0
105 ± 2.0
93 ± 5.9
46 ± 5.1
42 ± 8.7
% CBF
Control
100 ± 0
109 ± 4.5
98 ± 7.9
No signs
100 ± 0
99 ± 5.0
80 ± 9.1
Signs
100 ± 0
111 ± 8.0
290 ± 43.0
% AChE
Control
100 ± 0
100 ± 0
97 ± 4.1
95 ± 2.8
93 ± 4.6
No signs
100 ± 0
100 ± 0
57 ± 22.1
17 ± 8.9
8 ± 3.6
Signs
100 ± 0
100 ± 0
67 ± 10.4
6 ± 2.6
7 ± 1.4
% HR
Control
100 ± 0
97 ± 2.4
98 ± 2.0
99 ± 2.6
97 ± 2.6
97 ± 2.8
No signs
100 ± 0
93 ± 3.8
92 ± 4.3
93 ± 3.2
94 ± 2.8
91 ± 2.9
Signs
100 ± 0
100 ± 2.0
102 ± 1.9
105 ± 1.4
107 ± 3.2
102 ± 3.3
% pCO2
Control
100 ± 0
100 ± 0
93 ± 0.6
90 ± 1.4
89 ± 1.8
No signs
100 ± 0
100 ± 0
96 ± 2.9
96 ± 3.4
92 ± 4.7
Signs
100 ± 0
100 ± 0
94 ± 2.0
98 ± 2.9
105 ± 3.7
, paired comparisons from baseline value. , paired comparisons from baseline value.
