Coordinated Increased Expression of Cyclooxygenase2 and Nuclear Factor 𝜅B Is a Steady Feature of Urinary Bladder Carcinogenesis

Figure 1

(a) and (e)  Normal bladder epithelium. (a) Epithelial bladder cells exhibit no immunostaining for COX-2 (x200). (e) Strong positive cytoplasmic and negative nuclear expression for NF𝜅B (x200). (b) and (f) Well-differentiated UC (Grade I) (b) Epithelial bladder cells exhibit weak positive cytoplasmic immunostaining for COX-2 (x200). (f) Moderate nuclear and strong cytoplasmic immunostaining for NF𝜅B (x200). (c) and (g) Moderately differentiated UC (Grade II). (c) Epithelial bladder cells exhibit moderate cytoplasmic immunostaining for COX-2 (x200). (g) Strong nuclear and moderate cytoplasmic immunostaining for NF𝜅B (x200). (d) and (h) Poorly differentiated UC (Grade III). (d) Epithelial bladder cells exhibit strong cytoplasmic immunostaining for COX-2 (x200). (h) Strong nuclear immunostaining for NF𝜅B (x200).