Clinical Study

The Efficacy and Safety of Propiverine Hydrochloride in Patients with Overactive Bladder Symptoms Who Poorly Responded to Previous Anticholinergic Agents

Table 2

Changes in overactive bladder symptoms by previous anticholinergic agent and by gender.

VariablesOveractive bladder symptom scores
Baseline4 weeks12 weeksP-value(2)

Solifenacin ( 𝑛 = 2 7 ) 9 . 4 ± 2 . 5 (1) 7 . 2 ± 3 . 9 ** 6 . 5 ± 3 . 9 ** 𝑃 = 0 . 3 1
Tolterodine ( 𝑛 = 1 0 ) 8 . 4 ± 1 . 4 4 . 7 ± 1 . 7 ** 5 . 9 ± 2 . 5 *
Imidafenacin ( 𝑛 = 1 5 ) 8 . 7 ± 2 . 1 5 . 4 ± 2 . 2 ** 6 . 1 ± 2 . 8 **

Male ( 𝑛 = 2 1 ) 8 . 5 ± 1 . 9 6 . 9 ± 3 . 2 ** 6 . 4 ± 2 . 9 ** 𝑃 < 0 . 0 1
Female ( 𝑛 = 3 1 ) 9 . 4 ± 2 . 4 5 . 7 ± 3 . 3 ** 6 . 1 ± 3 . 6 **

(1)Mean ± standard deviation.
(2)Comparison among groups (combined analysis model).
* 𝑃 < 0 . 0 1 , ** 𝑃 < 0 . 0 0 1 (versus baseline, paired t-test).