TY - JOUR
A2 - Burger, Maximilian
AU - Otto, Wolfgang
AU - Gerber, Peter
AU - Rößler, Wolfgang
AU - Wieland, Wolf F.
AU - Denzinger, Stefan
PY - 2012
DA - 2011/10/03
TI - Predictive Value of Positive Surgical Margins after Radical
Prostatectomy for Lymph Node Metastasis in Locally Advanced
Prostate Carcinoma
SP - 618574
VL - 2012
AB - Introduction. Suspected locally advanced prostate carcinoma shows lymph node involvement in a high percentage of cases. For a long time, such patients were not radically prostatectomised. In recent years, however, this viewpoint has changed. Material and Methods. We analysed a single-centre series of 34 patients with suspected locally advanced prostate cancer to establish predictive parameters for lymph node metastasis. All patients underwent radical prostatectomy between 2007 and 2010. Results. Of the 34 patients, 26% showed pathological stage T3a, 59% pT3b, and 15% pT4. Median preoperative PSA level was 25 ng/mL, and five patients had had neoadjuvant antihormonal treatment. Positive margins were found in 76% of patients. Patients without neoadjuvant treatment showed it in 79%, and after preoperative antihormonal treatment the rate was 60%. Positive margins were associated with lymph node involvement in 85% of cases, complete resection was associated only in 50% of cases. Conclusions. Positive surgical margins play an important predictive role when estimating lymph node involvement in patients with locally advanced prostate carcinoma. Neoadjuvant antihormonal therapy is associated with a relevant reduction in the rate of positive margins but not with the rate of lymph node metastasis. As such, a combination of antihormonal and surgical treatment should be considered.
SN - 1687-6369
UR - https://doi.org/10.1155/2012/618574
DO - 10.1155/2012/618574
JF - Advances in Urology
PB - Hindawi Publishing Corporation
KW -
ER -