Radical Prostatectomy and Intraoperative Radiation Therapy in High-Risk Prostate Cancer

Table 1

Treatment modality and outcomes of selected series of IORT in prostate cancer.

	pts	Treatment modality	Local control	Overall survival; (5 years)	Morbidity, toxicity, and surgical complications
Takahashi et al. [9]	9	IORT(20–25 Gy) + PNLD + EBRT(50 Gy) ± HT—without RP	100% 5y	—	No severe toxicity
	5	IORT(30–35 Gy) + PNLD ± HT—without RP	80% 5y		No severe toxicity
Abe et al. [17]	21	IORT (28–35 Gy) single dose + PNLD—without RP; IORT(20–25 Gy) + EBRT(50 Gy) ± HT	81% 5y	72%	100% hematuria
Kojima et al. [10]	30	IORT(12–20 Gy) + PRP/RRP ± PNLD + EBRT ± HT	—	43%	—
Higashi et al. [11]	35	PNLD + IORT(25–30 Gy) + EBRT(30 Gy) ± HT—without RP	—	92% (stage B)	No severe toxicity
				87% (stage C)
Saracino et al. [12]	34	IORT(16–22 Gy) + RRP ± PNLD + EBRT ± HT	91%	—	No severe toxicity
Rocco et al. [19]	33	RRP + PNLD + IORT(12 Gy) + EBRT ± HT	—	—	1 lymphocele; 3 anastomotic stricture
Krengli et al. [14, 20]	38	RRP + PNLD + IORT(9–12 Gy) + EBRT ± HT	—	—	11% G2 GE toxicity
					4% G2 GU toxicity
					5 lymphocele
					2 pelvic hematoma

RP = radical prostatectomy, PRP = perineal radical prostatectomy, RRP = retropubic radical prostatectomy, PLND = pelvic lymphadenectomy, EBRT = external-beam radiation, HT = hormonal therapy, GE = gastro-enteric, GU = genito-urinary.