Differences in Upgrading of Prostate Cancer in Prostatectomies between Community and Academic Practices

Table 3

Multivariate logistic regression for risk of Gleason upgrading at radical prostatectomy.

	Odds ratio*	95% CI
Site of biopsy
Academic	1.00	Referent
Community	0.91	0.68–1.22 (P = 0.53)
Age at biopsy
<60	1.00	Referent
60–69	1.38	1.06–1.82 (P = 0.02)
≥70	2.82	1.87–4.28 (P < 0.01)
PSA
<4.0	1.00	Referent
4–9.9	1.77	1.27–2.47 (P < 0.01)
≥10	4.08	2.11–6.35 (P < 0.01)
Prostate size (cc)
<35	1.00	Referent
35–44	0.80	0.56–1.12 (P = 0.2)
44–56	0.65	0.45–0.93 (P = 0.02)
>56	0.51	0.35–0.74 (P = 0.04)
Total number of biopsy cores
<10	1.00	Referent
≥10	0.85	0.61–1.19 (P = 0.5)
Number of positive cores
One	1.00	Referent
Two	1.70	1.15–2.50 (P = 0.01)
Three	1.53	1.00–2.34 (P = 0.04)
Four or more	1.96	1.33–2.89 (P < 0.01)
Biopsy Gleason sum
3+3	1.00	Referent
3+4	0.39	0.29–0.52 (P < 0.01)

∗Odds ratios adjusted for all other variables in the table.