Higher Prostate Weight Is Inversely Associated with Gleason Score Upgrading in Radical Prostatectomy Specimens

Table 1

Patients’ demographics by Gleason score at biopsy versus radical prostatectomy (RP).

Feature	Gleason score			𝑃 value
	Biopsy < RP (upgraded)	Biopsy = RP	Biopsy > RP (downgraded)
Overall	128 (37.32%)	186 (54.23%)	29 (8.45%)
Age (Median/Min Max)	62.76 (43–76)	63.94 (46–76)	63.55 (46–74)	0.317
Race				0.522
White	98 (76.56%)	156 (83.87%)	24 (82.76%)
Black	28 (21.88%)	27 (14.52%)	5 (17.24%)
Yellow	2 (1.56%)	3 (1.61%)	0
PSA	10.29 (0.28–8.60)	8.95 (0.6–29.7)	11.1 (3.10–44)	0.192
Prostate weight	37.45 (15–94)	42.34 (11–190)	42.30 (15–110)	0.373
PSA density	0.31 (0.06–0.86)	0.25 (0.09–0.66)	0.19 (0.03–0.63)	<0.001
Clinical stage				0.019
T1c	52 (44.44%)	99 (56.25%)	8 (30.77%)
T2a	46 (39.32%)	58 (32.95%)	10 (38.46%)
T2b	13 (11.11%)	17 (9.66%)	7 (26.02%)
T2c	6 (5.13%)	2 (1.14%)	1 (3.85%)
Biopsy Gleason score				<0.001
≤6	115 (89.84%)	99 (53.23%)	0
7	13 (10.16%)	84 (45.16%)	19 (65.52%)
≥8	0	3 (1.61%)	10 (34.48%)
Pathological Gleason score				<0.001
≤6	0	100 (53.76%)	18 (62.07%)
7	112 (87.50%)	83 (44.62%)	11 (37.93%)
≥8	16 (12.50%)	3 (1.61%)	0
Pathological stage				0.05
≤pT2	81 (63.28%)	139 (74.73%)	23 (79.31%)
	47 (36.72%)	47 (25.27%)	6 (20.69%)
Positive points (tumor extent)
≤26	44 (37.93%)	98 (55.06%)	15 (60.00%)	0.009
	72 (62.07%)	80 (44.94%)	10 (40.00%)
Positive points (median/min max)	46.70 (1.00–33.50)	29.76 (0–222)	33.32 (1.0–152)	<0.001
“Insignificant” tumors*				<0.001
Yes	0 (0.00%)	22 (12.43%)	3 (12.50%)
No	116 (100.00%)	155 (87.57%)	21 (87.50%)
Positive surgical margin				<0.001
No	51 (40.16%)	114 (61.29%)	20 (68.97%)
Yes	76 (59.84%)	72 (38.71%)	9 (31.03%)
Extra prostatic extension				0.043
No	81 (63.78%)	141 (75.81%)	23 (79.31%)
Yes	46 (36.22%)	45 (24.19%)	6 (20.69%)
Seminal vesicle invasion				0.003
No	103 (82.40%)	174 (94.57%)	25 (86.21%)
Yes	22 (17.60%)	10 (5.43%)	4 (13.79%)

 *Based on classification of Billis et al. [6].