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Advances in Urology
Volume 2014, Article ID 524570, 4 pages
Research Article

Does an Association between the Idiopathic Left-Sided Varicocele and Eye Colour Exist?

Clinical Center of Endocrinology and Gerontology, Medical University of Sofia, 2 Zdrave Street, 1431 Sofia, Bulgaria

Received 18 January 2014; Revised 12 March 2014; Accepted 13 March 2014; Published 7 April 2014

Academic Editor: M. Hammad Ather

Copyright © 2014 Philip Kumanov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The possible interrelation between male reproductive disorders and iris pigmentation is poorly understood. We have found a link between eye colour and the existence of adolescent varicocele. Therefore, we aimed to extend our investigation on the relationship between the eye colour and varicocele in adult men. 231 andrology outpatients from Caucasian origin were included in the study. The presence of varicocele, sperm disturbances, and the iris pigment of the patients were investigated. Left-sided varicocele was found in 93 adults. In the group of light-eyed men the prevalence of varicocele was significantly lower than among the dark-eyed men (15% versus 59.5%, ). No associations were found between the eye colour and disturbances in semen parameters in males with varicocele ( ) and in those without varicocele ( ). The present results in adult men suggest that the prevalence of varicocele could be associated with the iris pigment. A possible genetic linkage between the eye colour and the susceptibility to some disorders like varicocele could not be excluded. However, the iris pigmentation seems not to have a direct relationship with the sperm disturbances.