IGF1 as a Potential Treatment for Rett Syndrome: Safety Assessment in Six Rett Patients
Figure 7
Effects of IGF1 treatment on brain activity. (a) Spectrum of frequencies (left) and EEG trace (right) for the site C4-T4 in all the treated subjects S1–S6 at D0 and D365. (b) Spectrum of frequencies (left) and EEG trace (right) for the site C4-T4 in all the untreated controls C1–C6 at D0 and D365. The color bar on the right shows intensity scale. (a) and (b): Frequencies spectrum Y-axis (blue plots) ranging between 0 and 15 Hz; X–axis ranging between 0 and 1700 sec. EEG traces Y-axis (white plots) ranging between −1.5 and +1.0 mV; X-axis ranging between 0 and 1700 sec. (c) Quantification of theta frequency (site C4-T4) in all the treated (T-red) and all the nontreated (NT-grey) RTT patients at D0 (non filled) and D365 (filled). There is a significant increase in theta frequency between the treated but not the untreated patients (Wilcoxon test).
