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Autism Research and Treatment
Volume 2013, Article ID 609705, 9 pages
http://dx.doi.org/10.1155/2013/609705
Clinical Study

Effectiveness of Methylcobalamin and Folinic Acid Treatment on Adaptive Behavior in Children with Autistic Disorder Is Related to Glutathione Redox Status

1Department of Pediatrics, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
2Department of Biostatistics, Arkansas Children’s Hospital Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA

Received 15 July 2013; Accepted 4 September 2013

Academic Editor: Klaus-Peter Ossenkopp

Copyright © 2013 Richard E. Frye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [22 citations]

The following is the list of published articles that have cited the current article.

  • Richard Eugene Frye, and Daniel A. Rossignol, “Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder,” Frontiers in Pediatrics, vol. 2, 2014. View at Publisher · View at Google Scholar
  • Richard E. Frye, and S. Jill James, “Metabolic pathology of autism in relation to redox metabolism,” Biomarkers in Medicine, vol. 8, no. 3, pp. 321–330, 2014. View at Publisher · View at Google Scholar
  • Richard E. Frye, “Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder,” Epilepsy & Behavior, 2014. View at Publisher · View at Google Scholar
  • Carmen Puig-Alcaraz, Milagros Fuentes-Albero, Jesús Calderón, Dolores Garrote, and Omar Cauli, “,” Psychiatry Research, 2015. View at Publisher · View at Google Scholar
  • Afaf El-Ansary, Ramesa Shafi Bhat, Sooad Al-Daihan, and Abeer M. Al Dbass, “The neurotoxic effects of ampicillin-associated gut bacterial imbalances compared to those of orally administered propionic acid in the etiology of pe,” Gut Pathogens, vol. 7, 2015. View at Publisher · View at Google Scholar
  • Feng Gu, Ved Chauhan, and Abha Chauhan, “Glutathione redox imbalance in brain disorders,” Current Opinion In Clinical Nutrition And Metabolic Care, vol. 18, no. 1, pp. 89–95, 2015. View at Publisher · View at Google Scholar
  • Natascia Brondino, Laura Fusar-Poli, Matteo Rocchetti, Umberto Provenzani, Francesco Barale, and Pierluigi Politi, “Complementary and Alternative Therapies for Autism Spectrum Disorder,” Evidence-Based Complementary and Alternative Medicine, vol. 2015, pp. 1–31, 2015. View at Publisher · View at Google Scholar
  • Kieran M. Tuohy, Paola Venuti, Simone Cuva, Cesare Furlanello, Mattia Gasperotti, Andrea Mancini, Florencia Ceppa, Duccio Cavalieri, Carlotta de Filippo, Urska Vrhovsek, Pedro Mena, Daniele Del Rio, and Francesca Fava, “Diet and the Gut Microbiota – How the Gut,” Diet-Microbe Interactions in the Gut, pp. 225–245, 2015. View at Publisher · View at Google Scholar
  • Richard E Frye, Shannon Rose, John Slattery, and Derrick F MacFabe, “Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome.,” Microbial ecology in health and disease, vol. 26, pp. 27458, 2015. View at Publisher · View at Google Scholar
  • Caihong Sun, Mingyang Zou, Dong Zhao, Wei Xia, and Lijie Wu, “Efficacy of Folic Acid Supplementation in Autistic Children Participating in Structured Teaching: An Open-Label Trial,” Nutrients, vol. 8, no. 6, pp. 337, 2016. View at Publisher · View at Google Scholar
  • Lawrence Scahill, Sangchoon Jeon, Susan J. Boorin, Christopher J. McDougle, Michael G. Aman, James Dziura, James T. McCracken, Sonia Caprio, L. Eugene Arnold, Ginger Nicol, Yanhong Deng, Saankari A. Challa, and Benedetto Vitiello, “Weight Gain and Metabolic Consequences of Risperidone in Young Children With Autism Spectrum Disorder,” Journal of the American Academy of Child & Adolescent Psychiatry, vol. 55, no. 5, pp. 415–423, 2016. View at Publisher · View at Google Scholar
  • Richard E. Frye, Manuel F. Casanova, S. Hossein Fatemi, Timothy D. Folsom, Teri J. Reutiman, Gregory L. Brown, Stephen M. Edelson, John C. Slattery, and James B. Adams, “Neuropathological Mechanisms of Seizures in Autism Spectrum Disorder,” Frontiers in Neuroscience, vol. 10, 2016. View at Publisher · View at Google Scholar
  • Richard E. Frye, Leanna Delhey, John Slattery, Marie Tippett, Rebecca Wynne, Shannon Rose, Stephen G. Kahler, Sirish C. Bennuri, Stepan Melnyk, Jeffrey M. Sequeira, and Edward Quadros, “Blocking and Binding Folate Receptor Alpha Autoantibodies Identify Novel Autism Spectrum Disorder Subgroups,” Frontiers in Neuroscience, vol. 10, 2016. View at Publisher · View at Google Scholar
  • Richard E. Frye, and Daniel A. Rossignol, “Identification and Treatment of Pathophysiological Comorbidities of Autism Spectrum Disorder to Achieve Optimal Outcomes,” Clinical Medicine Insights: Pediatrics, vol. 10, pp. CMPed.S38337, 2017. View at Publisher · View at Google Scholar
  • Daniel P Howsmon, Uwe Kruger, Stepan Melnyk, S Jill James, and Juergen Hahn, “Classification and adaptive behavior prediction of children with autism spectrum disorder based upon multivariate data analysis of markers of oxidative stress and DNA methylation.,” PLoS computational biology, vol. 13, no. 3, 2017. View at Publisher · View at Google Scholar
  • Keren K. Griffiths, and Richard J. Levy, “Evidence of Mitochondrial Dysfunction in Autism: Biochemical Links, Genetic-Based Associations, and Non-Energy-Related Mechanisms,” Oxidative Medicine and Cellular Longevity, vol. 2017, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  • John Slattery, and Richard Eugene Frye, “Application of N-Acetylcysteine in Psychiatric Disorders,” The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine, pp. 203–218, 2018. View at Publisher · View at Google Scholar
  • Richard E. Frye, “Social Skills Deficits in Autism Spectrum Disorder: Potential Biological Origins and Progress in Developing Therapeutic Agents,” CNS Drugs, 2018. View at Publisher · View at Google Scholar
  • Daniel P. Howsmon, Troy Vargason, Robert A. Rubin, Leanna Delhey, Marie Tippett, Shannon Rose, Sirish C. Bennuri, John C. Slattery, Stepan Melnyk, S. Jill James, Richard E. Frye, and Juergen Hahn, “Multivariate techniques enable a biochemical classification of children with autism spectrum disorder versus typically-developing peers: A comparison and validation study,” Bioengineering & Translational Medicine, 2018. View at Publisher · View at Google Scholar
  • Daoyin Dong, Horst Ronald Zielke, David Yeh, and Peixin Yang, “Cellular stress and apoptosis contribute to the pathogenesis of autism spectrum disorder,” Autism Research, 2018. View at Publisher · View at Google Scholar
  • Leanna M. Delhey, Marie Tippett, Shannon Rose, Sirish C. Bennuri, John C. Slattery, Stepan Melnyk, S. Jill James, and Richard E. Frye, “Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials,” Frontiers in Neuroscience, vol. 12, 2018. View at Publisher · View at Google Scholar
  • Roohi Mirza, and Bhupesh Sharma, “Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats,” Life Sciences, 2018. View at Publisher · View at Google Scholar