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Autism Research and Treatment
Volume 2014, Article ID 242048, 6 pages
Research Article

The Relationship of HLA Class I and II Alleles and Haplotypes with Autism: A Case Control Study

1College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11461, Saudi Arabia
2Autism Research and Treatment Center, Al-Amodi Autism Research Chair, Saudi Arabia

Received 12 August 2013; Revised 30 November 2013; Accepted 2 December 2013; Published 3 February 2014

Academic Editor: Mikhail V. Pletnikov

Copyright © 2014 Manan Al-Hakbany et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Earlier reports showed the relationship between autism and immune genes located in the human leukocyte antigen (HLA). In this current study, we compared the HLA class I and class II alleles and haplotypes in 35 autistic children with 100 control subjects from Saudi Arabia, using PCR-SSP method and Luminex technology. In class I the HLA-A*01 (, OR 2.68), A*02 (, OR 3.02) and HLA-B*07 (, OR 3.27), were significantly associated with autism. Also, the haplotype A*02-B*07 was significantly higher in autistic patients than in controls (, OR 5.83). In class II, DRB1*1104 was significantly higher in patients than in controls (, OR 8.75). The DQB1*0202 ( OR 0.24), DQB1*0302 ( OR 0.14), and DQB1*0501 ( OR 0.25), were negatively associated with disease. While the four-loci genotype study showed that A*01-B*07-DRB1*0701-DQB1*0602 ( OR 41.9) and the A*31-B*51-DRB1*0103-DQB1*0302 ( OR 4.8) are positively associated with autism among Saudi patients. This is the first report on a foreseeable risk of association of HLA-B*07 allele with autism. Thus, HLA-B*07 allele and the closely linked haplotype A*01 B*07 DRB1*0701 DQB1*0602 may serve as a marker for genetic susceptibility to autism in Saudis.