Associations between Familial Rates of Psychiatric Disorders and De Novo Genetic Mutations in Autism

Table 3

Rate of psychiatric disorders group comparisons by familial relation.

	DEL	DUP	LGDM	NON	A priori comparisons
Overall rates	0.015	0.022	0.017	0.020	NON < DEL; DEL < DUP; LGDM < DUP
Anxiety disorders	0.028	0.033	0.023	0.029
Bipolar disorders	0.014	0.025	0.016	0.017
Depressive disorders	0.046	0.077	0.067	0.077	DEL < DUP; DEL < LGDM; DEL < NON; LGDM < NON
Feeding/eating disorders	0.007	0.005	0.000	0.004
Neurodevelopmental disorders	0.007	0.014	0.018	0.016
Obsessive compulsive disorders	0.004	0.011	0.006	0.007
Schizophrenia/psychotic disorders	0.005	0.006	0.002	0.004
Trauma/stress disorders	0.005	0.005	0.004	0.003
Maternal rates	0.018	0.022	0.022	0.024	DEL < NON
Anxiety disorders	0.028	0.028	0.032	0.037
Bipolar disorders	0.003	0.018	0.015	0.018
Depressive disorders	0.069	0.087	0.081	0.096	DEL < NON; LGDM < NON
Feeding/eating disorders	0.015	0.004	0.001	0.005
Neurodevelopmental disorders	0.006	0.014	0.025	0.020	DEL < LGDM
Obsessive compulsive disorders	0.008	0.015	0.010	0.008
Schizophrenia/psychotic disorders	0.006	0.003	0.003	0.004
Trauma/stress disorders	0.005	0.006	0.007	0.005
Paternal rates	0.012	0.022	0.012	0.015	DEL < DUP; LDGM < DUP; NON < DUP
Anxiety disorders	0.029	0.038	0.014	0.020	LGDM < DUP; NON < DUP
Bipolar disorders	0.025	0.032	0.018	0.015
Depressive disorders	0.022	0.067	0.052	0.057	DEL < DUP; DEL < LGDM; DEL < NON
Feeding/eating disorders	0.000	0.005	0.000	0.002
Neurodevelopmental disorders	0.008	0.014	0.011	0.013
Obsessive compulsive disorders	0.000	0.006	0.001	0.005
Schizophrenia/psychotic disorders	0.005	0.009	0.002	0.005
Trauma/stress disorders	0.005	0.004	0.001	0.002