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Autism Research and Treatment
Volume 2018, Article ID 5093016, 8 pages
Research Article

A Study of the Correlation between VEP and Clinical Severity in Children with Autism Spectrum Disorder

1Kanchanabhishek Institute of Medical and Public Health Technology, Nonthaburi 11150, Thailand
2Research Center for Neuroscience, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom 73170, Thailand
3Department of Occupational Therapy, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom 73170, Thailand

Correspondence should be addressed to Vorasith Siripornpanich; moc.liamg@htisarovrd

Received 25 September 2017; Revised 1 December 2017; Accepted 14 December 2017; Published 14 January 2018

Academic Editor: Klaus-Peter Ossenkopp

Copyright © 2018 Winai Sayorwan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Visual evoked potential (VEP) is a technique used to assess the brain’s electrical response to visual stimuli. The aims of this study were to examine neural transmission within the visual pathway through VEP testing in preschool children with autism spectrum disorder (ASD) and compare it to age-matched controls, as well as search for a correlation between the VEP parameters and the symptoms of ASD. Participants were composed of ASD children (9 males) and typically developing children (8 males and 4 females), aged between 3 and 5 years. Checkerboards were chosen as the pattern-reversal VEP. The clinical severity of ASD was assessed using the Autism Treatment Evaluation Checklist (ATEC) and the Vineland Adaptive Behavior Scales 2nd edition (VABS-II). Our findings demonstrated that children with ASD had significantly longer N145 latency compared to the controls. A longer N145 latency correlated with a higher score of ATEC within the sensory/cognitive awareness subdomain. In addition, a slower N145 response was also associated with a lower VABS-II score within the socialization domain. The correlation between longer VEP latency and abnormal behaviors in children with ASD suggests a delayed neural communication within other neural circuits, apart from the visual pathway. These lines of evidence support the possibility of using VEP, along with clinical parameters, for the assessment of ASD severity.