Improving Outcome in Infantile Autism with Folate Receptor Autoimmunity and Nutritional Derangements: A Self-Controlled Trial

Table 2

The upper part shows the CARS score in function of age in the reference group of 84 untreated children with infantile autism. The table below shows the effect of treatment after 2 years upon the CARS score evolution in 82 children with a significant decrease for each age group. The lowest part of the table shows the CARS at baseline and after two-year treatment for 66 families in function of the profile of positive (+) or negative (-) FRα autoantibodies in the child, mother, or father. N stands for the number of subjects.

(a)

Age	N	CARS score
1	1	36.5
2	20	41.92 ± 5.4
3	21	41.12 ± 6.7
4	21	40.33 ± 7.56
5	9	39.05 ± 4.07
≥ 6	12	41.75 ± 4.25

(b)

Age	N	CARS at baseline	CARS after treatment	paired t-test	p value
		( Mean ± SD)	( Mean ± SD)
1	1	38	38
2	10	39.35 ± 5.2	33.6 ± 4.9	3.31	0.009
3	31	40.01 ± 5.8	33.96 ± 5.9	7.79
4	19	41.37 ± 6.7	34 ± 7.9	4.66	0.0002
5	10	42.8 ± 8.2	33.55 ± 5.5	4.99	0.0007
≥ 6	11	45.09 ± 6.46	37.7 ± 5.15	6.02	0.0001

(c)

FRα antibody profile			N	CARS at baseline	CARS after treatment	paired t-test	p value
Child	Mother	Father		( Mean ± SD)	(Mean ± SD)
+	-	-	23	39,06 ± 6,17	34,28 ± 4,21	4.86
+	+	-	11	40,54 ± 3,71	33,14 ± 4,42	5.64	0.0002
+	-	+	11	41.5 ± 9.08	32.32 ± 7.6	4.49	0.0012
-	-	-	9	42.05 ± 6.8	33.88 ± 8.19	7.6
-	+	-	5	43.5 ± 6.5	38 ± 7.06	3.41	0.027
+	+	+	7	46.14 ± 4.8	42.21 ± 3.8	2.61	0.0398