Review Article

Arenavirus Budding

Figure 3

Model of arenavirus budding. Myristoylation of Z at G2 facilitates its interaction with the plasma membrane (PM), where Z likely forms higher-order complexes. L domains located within the C-terminus of Z facilitate its interactions with host cellular factors to allow Z to utilize the ESCRT machinery of the cell for cell egress (budding). SSP, stable signal peptide.
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