The Role of Plasmacytoid Dendritic Cells in Innate and Adaptive Immune Responses against Alpha Herpes Virus Infections

Figure 2

Proposed model for the plasmacytoid dendritic cell (PDC) “life cycle”, which is based on the timely coordinated expression of surface markers after contact with herpes simplex virus (HSV). The upper part of the figure depicts the attraction of PDC to inflamed tissue, where they take up their antigen and interact with local effector cells. Then, PDC reenter the blood stream and home to secondary lymphatic tissue via high endothelial venules (HEV), where they shape the adaptive immune response via interaction with naïve T cells, as outlined at the lower part of the figure.