Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors—A Consequence of Evolutionary Pressure?

Figure 4

Relative sequence length and putative phosphorylation sites of the C-terminal region of class A 7TM receptors and the BILF-like receptors. The vertical axis displays the number of amino acids of the C-terminus (blue), defined as being after the highly conserved proline of the NPxxY-motif (class A 7TM receptors) or predicted by the Transmembrane Hidden Markov model using Geneious Pro (BILF receptor family), and the number of serine, threonine, and tyrosine in this region (beige). The horizontal axis displays the average of 334 non-olfactory class A 7TM receptors (1) and the EBV-encoded BILF receptors (2–9). For further details about specific receptors and GenBank accession number please see Table 2.