Advances in Virus-Directed Therapeutics against Epstein-Barr Virus-Associated Malignancies

Table 1

Available therapies for EBV diseases.

Modalities	Classification	Comments
Drug treatment	Acyclovir/ganciclovir	Inhibits virus replication and induces cell killing. Effective only against lytic EBV infection.
Immunotherapy	Vaccination	Recombinant gp350-based vaccine, CTL epitope peptide-based vaccine.
	Treatment of disease	Monoclonal antibody against CD21, anti CD-20 antibody (Rituximab); EBV-specific cytotoxic T cells from donor or ex vivo amplification of CTLs from patients and infusion back to the patient.
Virus-directed approaches	Utilization of presence of virus in the tumor	Various cell-killing strategies that are dependent on EBV gene expression.