Retargeting of Viruses to Generate Oncolytic Agents

Figure 4

In vivo oncolytic activity of murine coronavirus MHV. Mice with established intracranial U87ΔEGFR tumors were treated with MHV genetically redirected to the EGFR (MHVsoR-EGF-His), the His-receptor (MHVsoR-his), or with PBS. (a) Survival curves. (b) Histopathological analysis of brains at day 9 posttreatment and at the day of euthanasia (day > 9). Large neoplasms and cystic structures are indicated by “N” and “C,” respectively. (c) Immunostaining of brains after treatment with MHVsoR-EGF-His using polyclonal anti-MHV antibodies (Copyright © American Society for Microbiology, Journal of Virology, Vol. 83, No. 15, P. 7507-16, 2009, DOI 10.1128/JVI.00495-09).

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