Epstein-Barr Virus as a Trigger of Autoimmune Liver Diseases

Table 2

Regional amino acid similarity between human cytochrome p450 IID6 (CYP2D6)_257–271 (the immunodominant epitope of anti-liver kidney microsomal antibodies type 1 in patients with autoimmune hepatitis type 2, and viral sequences originated from hepatitis C, herpes virus 1 (HSV-1), and Ebstein-Barr virus (EBV)). Amino acids (aa) in single letter code. Identical amino acids between human and viral sequences are indicated in bold.

Species

Protein

Code

Hepatitis C virus (HCV)

Non structural protein 5B

NS5B

P

P

G

D

P

P

Q

P

E

Y

D

L

Hepatitis C virus (HCV)

Envelope 1

E1

I

T

G

H

R

M

A

W

D

M

M

M

Human

Cytochrome P450IID6

CYP2D6

aa254

L

T

E

H

R

M

T

W

D

P

A

Q

P

P

R

D

L

271

Herpes simplex virus type 1 (HSV-1)

Immediate early 175 kDa

IE175

L

S

P

R

P

P

A

Q

P

P

R

R

R

Epstein-Barr virus (EBV)

Nuclear protein EBNA

EBNA

P

P

P

A

A

P

A

Q

P

P

P

G

V

Epstein-Barr virus (EBV)

Virion protein BVRF1

UL25

H

V

L

I

D

P

A

R

L

P

R

D

T