Advances in Virology / 2013 / Article / Fig 1

Review Article

Viruses as Modulators of Mitochondrial Functions

Figure 1

Schematic diagram of cell showing mitochondria, nucleus endoplasmic reticulum (ER) and cell membrane. iCa2+: intracellular calcium, FADD: Fas-associated protein with death domain, TRADD: tumor necrosis factor receptor type 1-associated death domain protein, PTP: permeability transition pore, VDAC: voltage-dependent anion channel, IP3R: inositol 1,4,5-trisphosphate receptor, RyR: ryanodine receptor, MAVS: mitochondrial antiviral signaling, I, II, III, and IV are complex I to IV of electron transport chain. : Superoxide radical, Bad, Bcl-2-associated death promoter, ROS: reactive oxygen species, IFN: interferon, HCMV: human cytomegalovirus, HIV: human immunodeficiency virus, HSV: herpes simplex virus, HBV: hepatitis B virus, HTLV: human T-lymphotropic virus, IA: influenza A virus, WDSV: Walleye dermal sarcoma virus, HCV: hepatitis C virus, HAdV: human adenovirus-5, EBV: Epstein-Barr virus, and EMCV: encephalomyocarditis virus.