Review Article

Characterization of the Protective HIV-1 CTL Epitopes and the Corresponding HLA Class I Alleles: A Step towards Designing CTL Based HIV-1 Vaccine

Table 2

List of optimal CTL epitopes for HIV-1 (taken and modified from HIV molecular immunology database (http://www.hiv.lanl.gov/content/immunology/tables/optimal_ctl_summary.html).

HIV protein AA positionHLA Sequence Clade

gp1602–10 B*0801 (B8) RVKEKYQHL
gp160 31–39 B*1801 (B18) AENLWVTVY B
gp160 31–39 B44 AENLWVTVY B
gp160 31–40 B*4402 (B44) AENLWVTVYY
gp160 37–46 A*0301 (A3) TVYYGVPVWK A, B, C, D
gp16042–51 B*5501 (B55) VPVWKEATTT
gp160 42–52 B*3501 (B35) VPVWKEATTTL B
gp160 52–61 A*2402 (A24) LFCASDAKAY
gp160 59–69 B58 KAYETEVHNVW C
gp160 61–69 B*1801 (B18) YETEVHNVW B
gp160 78–86 B*3501 (B35) DPNPQEVVL B
gp160 104–112 B*3801 (B38) MHEDIISLW B
gp160 199–207 A*1101 (A11) SVITQACPK B
gp160 209–217 A*2902 (A29) SFEPIPIHY B, D
gp160 298–307 B*0702 (B7) RPNNNTRKSI B, C
gp160310–318 A*3002 (A30) HIGPGRAFY B
gp160 311–320 A*0201 (A2) RGPGRAFVTI A, B, C
gp160 375–383 B*1516 (B63) SFNCGGEFF A, B, C
gp160 375–383 Cw*0401 (Cw4) SFNCGGEFF A, B, C
gp160 416–424 B*5101 (B51) LPCRIKQIIB
gp160 419–427 A*3201 (A32) RIKQIINMW B, C
gp160 511–519 Cw18 YRLGVGALI C
gp160 557–565 Cw*0304 (Cw10) RAIEAQQHL A, B, C, D
gp160 557–565 Cw8 RAIEAQQHM A, B, C, D
gp160 557–565 Cw15 RAIEAQQHL C
gp160 584–592 B*1402 (B14) ERYLKDQQL A, B, C, D
gp160 585–593 A23 RYLKDQQLL B, C
gp160 585–593 A*2402 (A24) RYLKDQQLL B, C
gp160 586–593 B*0801 (B8) YLKDQQLL A, B
gp160 606–614 B*3501 (B35) TAVPWNASW B
gp160 698–707 A*3303 (A33) VFAVLSIVNR B
gp160 703–712 A*2501 (A25) EIIFDIRQAY
gp160 704–712 A*3002 (A30) IVNRNRQGY B
gp160 770–780 A*0301 (A3) RLRDLLLIVTR B, C
gp160 770–780 A*3101 (A31) RLRDLLLIVTR B, C
gp160 777–785 A*6802 (A68) IVTRIVELL B
gp160 786–795 B*2705 (B27) GRRGWEALKY B
gp160 787–795 A*0101 (A1) RRGWEVLKY B
gp160 794–802 A*3002 (A30) KYCWNLLQY B
gp160 805–814 B*4001 (B60) QELKNSAVSL B
gp160 813–822 A*0201 (A2) SLLNATDIAV B
gp160 831–838 A*3303 (A33) EVAQRAYR B
gp160 843–851 B*0702 (B7) IPRRIRQGL A, B, C, D
gp160 846–854 A*0205 (A2) RIRQGLERA B
gp160 848–856 B8 RQGLERALL
Integrase 28–36 B42 LPPIVAKEI B, C
Integrase 66–74 B*1510 (B71) THLEGKIIL B, C
Integrase 123–132 B57 STTVKAACWW B
Integrase 135–143 B*1503 (B72) IQQEFGIPY B, C
Integrase 165–172 Cw18 VRDQAEHLC
Integrase 173–181 B*5701 (B57) KTAVQMAVF B
Integrase 179–188 A*0301 (A3) AVFIHNFKRK B, multiple
Integrase 179–188 A*1101 (A11) AVFIHNFKRK B, multiple
Integrase 185–194 B*1503 (B72) FKRKGGIGGY B, C
Integrase 203–211 A*1101 (A11) IIATDIQTK B
Integrase 219–227 A*3002 (A30) KIQNFRVYY AE, B, C, D
Integrase 260–268 B42 VPRRKAKII
Integrase 263–271 B*1503 (B72) RKAKIIRDY B, C
Nef 13–20 B*0801 (B8) WPTVRERM B
Nef 19–27 B62RMRRAEPAA B
Nef 37–45 B*4001 (B60) LEKHGAITS B
Nef 37–45 B50 LEKHGAITSB
Nef 68–76 B*0702 (B7) FPVTPQVPL B
Nef 68–77 B*0702 (B7) FPVTPQVPLR B
Nef 71–79 B*0702 (B7) TPQVPLRPM B
Nef 71–79 B*4201 (B42) RPQVPLRPM B, C
Nef 73–82 A*0301 (A3) QVPLRPMTYK A, B, C, D
Nef 73–82 A*1101 (A11) QVPLRPMTYK A, B, C, D
Nef 74–81 B*3501 (B35) VPLRPMTY A, B, C, D
Nef 75–82 A*1101 (A11) PLRPMTYK B
Nef 77–85 B*0702 (B7) RPMTYKAAL B
Nef 82–91 Cw8 KAAVDLSHFL B
Nef 83–91 A*0205 (A2) GAFDLSFFL A
Nef 83–91 Cw3 AALDLSHFL B
Nef 83–91 Cw*0802 (Cw8) AAVDLSHFL B, C
Nef 84–92 A*0301 (A3) AVDLSHFLK A, B, D, F
Nef 84–92 A*1101 (A11) AVDLSHFLK A, B, D, F
Nef 90–97 B*0801 (B8) FLKEKGGL A, B, C, D
Nef 92–100 B*4001 (B60) KEKGGLEGL B, C
Nef 92–100 B*4002 (B61) KEKGGLEGL B, C
Nef 105–114 B*2705 (B27) RRQDILDLWI B
Nef 105–115 B18 RRQDILDLWVY B
Nef 105–115 Cw7 KRQEILDLWVY B, C
Nef 106–114 B13 RQDILDLWI B
Nef 106–115 B*0702 (B7) RQDILDLWIY
Nef 116–124 B57 HTQGYFPDW B, C
Nef 116–125 B*5701 (B57) HTQGYFPDWQ B, C
Nef 117–127 B*1501 (B62) TQGYFPDWQNY B, C
Nef 120–128 A29 YFPDWQNYT B, C
Nef 120–128 B*3701 (B37) YFPDWQNYT B, C
Nef 120–128 B*5701 (B57) YFPDWQNYTB, C
Nef 120–128 Cw6 YFPDWQNYT B, C
Nef 127–135 B57 YTPGPGIRY B, C
Nef 127–135 B63 YTPGPGIRY B, C
Nef 128–137 B*0702 (B7) TPGPGVRYPL B, C
Nef 128–137 B*4201 (B42) TPGPGVRYPL B, C
Nef 133–141 A33 TRYPLTFGW B
Nef 134–141 A*2402 (A24) RYPLTFGWB, C
Nef 135–143 B*1801 (B18) YPLTFGWCY B, C, D
Nef 135–143 B53 YPLTFGWCF B
Nef 135–143 B*5301 (B53) YPLTFGWCY B
Nef 136–145 A*0201 (A2) PLTFGWCYKL B
Nef 137–145 B57 LTFGWCFKL A, B, C
Nef 137–145 B63 LTFGWCFKL A, B, C
Nef 180–189 A*0201 (A2) VLEWRFDSRL B
Nef 183–191 B*1503 (B72) WRFDSRLAF B
p17 11–19 B*4002 (B61) GELDRWEKI B
p17 18–26 A*0301 (A3) KIRLRPGGK A, B
p17 19–27 B*2705 (B27) IRLRPGGKK B
p17 20–28 A*0301 (A3) RLRPGGKKK A, B
p17 20–29 A*0301 (A3) RLRPGGKKKY B
p17 24–32 B*0801 (B8) GGKKKYKLK B, F
p17 28–36 A*2402 (A24) KYKLKHIVW B, C, F
p17 33–41 Cw*0804 (Cw8) HLVWASRELC
p17 34–44 A30 LVWASRELERF B, C
p17 36–44 B*3501 (B35) WASRELERF B, C
p17 74–82 B*0801 (B8) ELRSLYNTV F
p17 76–86 A*3002 (A30) RSLYNTVATLY B, C, F
p17 76–86 B58 RSLYNTVATLY B, C, F
p17 76–86 B63 RSLYNTVATLY B, C, F
p17 77–85 A*0201 (A2) SLYNTVATL A, B, C, D, F, G, K
p17 77–85 A*0202 (A2) SLYNTVATL A, B, C, D, F, G, K
p17 77–85 A*0205 (A2) SLYNTVATL A, B, C, D, F, G, K
p17 78–85 Cw14 LYNTVATL B, D
p17 78–86 A*2902 (A29) LYNTVATLY B, C
p17 78–86 B*4403 (B44) LYNTVATLYB, C
p17 84–91 A*1101 (A11) TLYCVHQK
p17 92–101 B*4001 (B60) IEIKDTKEAL B, F
p17 124–132 B*3501 (B35) NSSKVSQNY B
p243–11 B13 VQNLQGQMV B, C
p24 12–20 B*1510 (B71) HQAISPRTL B
p24 13–23 A*2501 (A25) QAISPRTLNAW B
p24 15–23 B*5701 (B57) ISPRTLNAW A, C
p24 15–23 B63 ISPRTLNAW A, B, C, D
p24 16–24 B*0702 (B7) SPRTLNAWV B
p24 24–32 B*1503 (B72) VKVIEEKAF B, C
p24 28–36 B*4415 (B12) EEKAFSPEVA, B, C, D
p24 30–37 B*5703 (B57) KAFSPEVI B
p24 30–40 B*5701 (B57) KAFSPEVIPMF A, B, C, G
p24 30–40 B*5703 (B57) KAFSPEVIPMF A, B, C, G
p24 30–40 B63 KAFSPEVIPMF A, B, C, G
p24 32–40 B57 FSPEVIPMF B, C
p24 35–43 A*2601 (A26) EVIPMFSAL A, B, C, D
p24 36–43 Cw*0102 (Cw1) VIPMFSALB, D
p2444–52 B*4001 (B60) SEGATPQDL B
p2448–56 B*0702 (B7) TPQDLNTML A, B, C, D
p24 48–56 B*3910 (B39) TPQDLNTML A, B, C, D
p24 48–56 B*4201 (B42) TPQDLNTML A, B, C, D
p24 48–56 B*5301 (B53) TPYDINQML A
p24 48–56 B*8101 (B81) TPQDLNTML A, B, C, D
p24 48–56 Cw*0802 (Cw8) TPQDLNTML A, B, C, D
p24 61–69 B*1510 (B71) GHQAAMQML B, C
p24 61–69 B*3901 (B39) GHQAAMQML B, C
p24 70–78 B*4002 (B61) KETINEEAA B
p24 71–80 A*2501 (A25) ETINEEAAEW A, B, D
p24 78–86 B*4002 (B61) AEWDRVHPV B
p24 84–92 B7 HPVHAGPIA B, C, D, F
p24 94–104 B13 GQMREPRGSDI B, C
p24 108–117 B*5701 (B57) TSTLQEQIGW B, C
p24 108–117 B*5801 (B58) TSTLQEQIGW B, C
p24 122–130 B*3501 (B35) PPIPVGDIY A, B, C
p24 128–135 B*0801 (B8) EIYKRWII B
p24 131–140 B*2703 (B27) RRWIQLGLQK
p24 131–140 B*2705 (B27) KRWIILGLNK A, B, C, D
p24 137–145 B*1501 (B62) GLNKIVRMY A, B
p24 142–150 Cw18 VRMYSPVSI B, C, F
p24 143–150 B*5201 (B52) RMYSPTSI B, F
p24 161–169 Cw18 FRDYVDRFF C
p24 161–170 B*1801 (B18) FRDYVDRFYK B, D
p24 162–172 A*2402 (A24) RDYVDRFFKTL A
p24 162–172 B*4402 (B44) RDYVDRFYKTL B, D
p24 164–172Cw*0303 (Cw9) YVDRFFKTL A, C, D
p24 164–172 A*0207 (A2) YVDRFYKTL B
p24 164–172 B*1503 (B72) YVDRFFKTL A, C, D
p24 164–172 Cw*0304 (Cw10)YVDRFFKTL A, C, D
p24 166–174 B*1402 (B14) DRFYKTLRA B, D
p24 174–184 B*4402 (B44) AEQASQDVKNWB, C, D
p24 174–185 Cw5 AEQASQEVKNWM
p24 176–184 B*5301 (B53) QASQEVKNW B, D
p24 176–184 B*5701 (B57) QASQEVKNW C
p24 197–205 B*0801 (B8) DCKTILKAL B
p24 217–227 A*1101 (A11) ACQGVGGPGHK B
p24 223–231 B*0702 (B7) GPGHKARVL B, C, D, F
Protease 3–11 A*6802 (A68) ITLWQRPLV A, B, C, D
Protease 3–11 A*7401 (A19) ITLWQRPLV A, B, C, D
Protease 30–38 A*6802 (A68) DTVLEEWNL D
Protease 34–42 B44 EEMNLPGRW B
Protease 57–66 B13 RQYDQILIEI B
Protease 68–76 B*1503 (B72) GKKAIGTVL BC
Protease 70–77 B57 KAIGTVLV BC
Protease 76–84 A*0201 (A2) LVGPTPVNI B
Protease 80–90 B81 TPVNIIGRNML C
Rev 14–23 B*5701 (B57) KAVRLIKFLY B
Rev 14–23 B*5801 (B58) KAVRLIKFLY B
Rev 14–23 B63 KAVRLIKFLY B
Rev 41–50 B7 RPAEPVPLQL A, B, C, D, F
Rev 57–66 A*0301 (A3) ERILSTYLGR B
Rev 67–75 Cw*0501 SAEPVPLQL B
RT 5–12 B*4001 (B60) IETVPVKLB
RT 18–26 B*0801 (B8) GPKVKQWPL A, B, C, D
RT 33–41 A*0201 (A2) ALVEICTEM B
RT 33–43 A*0301 (A3) ALVEICTEMEK B
RT 42–50 B*5101 (B51) EKEGKISKIB
RT 73–82 A*0301 (A3) KLVDFRELNK B
RT 93–101 A*0301 (A3) GIPHPAGLK B
RT 107–115 B*3501 (B35) TVLDVGDAY AG, B
RT 118–127 B*3501 (B35) VPLDEDFRKY B, C
RT 127–135 A2 YTAFTIPSV
RT 128–135 B*5101 (B51) TAFTIPSIB
RT 137–146 B18 NETPGIRYQY B, C
RT 142–149 B*1401 (B14) IRYQYNVL C
RT 156–164 B7 SPAIFQSSM A, B, C, D
RT 158–166 A*0301 (A3) AIFQSSMTK A, B, C, D
RT 158–166 A*1101 (A11) AIFQSSMTK
RT 173–181 A*3002 (A30) KQNPDIVIY B
RT 175–183 B18 NPEIVIYQY C
RT 175–183 B*3501 (B35) HPDIVIYQY A, B
RT 179–187 A*0201 (A2) VIYQYMDDL A, B, C, D
RT 202–210 B*4001 (B60) IEELRQHLL B
RT 244–252 B*5701 (B57) IVLPEKDSWB
RT 260–271 B*1501 (B62) LVGKLNWASQIY B
RT 263–271 A*3002 (A30) KLNWASQIY B, C
RT 269–277 A*0301 (A3) QIYPGIKVR B, C
RT 271–279 B*4201 (B42) YPGIKVRQL B, C
RT 309–317 A*0201 (A2) ILKEPVHGV A, B, C, D
RT 309–318 B*1501 (B62) ILKEPVHGVY A, B, D
RT 333–341 B13 GQGQWTYQI B
RT 341–350 A*1101 (A11) IYQEPFKNLK B, C
RT 356–365 A*3002 (A30) RMRGAHTNDV B
RT 356–366 A*0301 (A3) RMRGAHTNDVK B
RT 375–383 B*5801 (B58) IAMESIVIW B, C
RT 392–401 A*3201 (A32) PIQKETWETWB
RT 436–445 A*6802 (A68) GAETFYVDGA B, C
RT 438–448 A66 ETFYVDGAANR B, C
RT 449–457 A*2601 (A26) ETKLGKAGY B
RT 495–503 Cw*0802 (Cw8) IVTDSQYAL
RT 496–505 B*1503 (B72) VTDSQYALGI
RT 520–528 A*1101 (A11) QIIEQLIKK B
RT 560–568 B81 LFLDGIDKA
Tat 2–11 B*5301 (B53) EPVDPRLEPW B
Tat 2–11 B58 EPVDPRLEPW B
Tat 30–37 Cw12 CCFHCQVC B
Tat 38–47 B*1503 (B72) FQTKGLGISY C
Tat 39–49 A*6801 (A68) ITKGLGISYGR B
Vif 17–26 A*0301 (A3) RIRTWKSLVK B
Vif 28–36 A*0301 (A3) HMYISKKAK B
Vif 31–39 B*5701 (B57) ISKKAKGWF B
Vif 48–57 B*0702 (B7) HPRVSSEVHI B
Vif 57–66 B51 IPLGDAKLIIB
Vif 79–87 B*1510 (B71) WHLGHVSI B
Vif 79–87 B*3801 (B38) WHLGQGVSI B
Vif 102–111 B*1801 (B18) LADQLIHLHY B
Vif 158–168 A*0301 (A3) KTKPPLPSVKK B
Vpr 29–37 B51 EAVRHFPRIB
Vpr 30–38 B*5701 (B57) AVRHFPRIW B, C
Vpr 31–39 B27 VRHFPRIWL B
Vpr 34–42 B*0702 (B7) FPRIWLHGL B
Vpr 34–42 B*8101 (B81) FPRIWLHGL B
Vpr 48–57 A*6802 (A68) ETYGDTWTGV C
Vpr 52–62 A*6801 (A68) DTWAGVEAIIR B
Vpr 59–67 A*0201 (A2) AIIRILQQL B
Vpu 29–37 A*3303 (A33) EYRKILRQR B
Gag-Pol24–31 Cw*0102 (Cw1) NSPTRREL
p2p7p1p6 1–10 B*4501 (B45) AEAMSQVTNS
p2p7p1p6 42–50 B14 CRAPRKKGC B
p2p7p1p6 64–71 B*4002 (B61) TERQANFL B
p2p7p1p6 66–74 B13 RQANFLGKI B, C
p2p7p1p6 70–79 A*0201 (A2) FLGKIWPSYK B
p2p7p1p6 118–126 B*4001 (B60) KELYPLTSLB