Research Article
Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009–2013
Table 2
Year-wise samples showing amino acid changes in different domains of NS1 gene.
| | Domain | Position | Prevalence of mutation in samples each year | | 2009 (18) | 2010 (21) | 2011 (17) | 2012 (22) | 2013
(13) |
| | RNA binding domain | I 43 N | 1 | — | — | — | — | | D 53 N | 2 | — | — | — | — | | E 55 Q | 3 | 16 | 6 | — | 1 | | E 55 K | — | — | — | — | 1 | | K 62 R | — | 1 | 1 | — | — | | S 73 T | — | 1 | 3 | — | — |
| | Effector domain | L 90 I | — | — | 8 | all | all | | T 94 A | 2 | — | — | — | — | | E 96 K | — | 2 | — | — | — | | R 108 K | 4 | — | — | — | — | | I 123 V | 16 | 20 | all | all | all | | V 129 A | 1 | — | 1 | — | — | | V 129 I | — | — | 6 | — | — | | K 131 E | — | — | — | — | 4 | | K 131 Q | — | — | — | 2 | — | | I 145 L | — | 1 | — | — | — | | I 145 V | — | 5 | 1 | — | — | | L 147 R | — | — | 1 | — | — | | T 151 P | — | 1 | — | — | — | | E 172 K | 2 | — | — | — | — | |
A 202 P | — | — | — | — | 1 | | N 205 S | — | — | 13 | all | all | | N 209 D | 2 | 1 | — | — | — |
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