Research Article

Appearance of L90I and N205S Mutations in Effector Domain of NS1 Gene of pdm (09) H1N1 Virus from India during 2009–2013

Table 5

Cluster specific amino acid changes were seen in all the sequences of cluster and were absent from sequences of all other clusters.

ClustersSitesCluster specific amino acid changes

KOL 507
(2007, 2009)
13D26, N53, C59, L85, V95, N143 (99%), T145, N171, T209, F214, T216, T217, T226

KOL 596
(2007, 2009)
7P3, R59, A60, S103, I106, A171, I226

KOL 989
(2007–2009)
19V23, R41, A56, H59, K67, V82, T84, I95, L98, N101, E112, M129 (80%), I144, V145, I171, K196, R224, A226, K229

NIV 6196
(2009–2013)
28M6, F22, N25 (99%), G26, L59, W67, S74, T76, R78, I81, T86, S91, R108 (99%), I111 (90%), I112, L119, V123 (85%), V129, N139, Y171, I198, N205 (77%), C206, D207, S213, P215, E217, *220

Some cluster specific changes were seen in variable percentage of sequences in cluster and those absent from all other clusters are highlighted with italic font.