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Advances in Virology
Volume 2015 (2015), Article ID 537939, 7 pages
http://dx.doi.org/10.1155/2015/537939
Research Article

Seroprevalence of Herpes Simplex Virus Infection in HIV Coinfected Individuals in Eastern India with Risk Factor Analysis

1Department of Microbiology, IIMSAR & BCRH, Haldia, West Bengal, India
2Department of Microbiology, Medical College Kolkata, 88 College Street, Kolkata, West Bengal, India
3ICMR Virus Unit, I.D. and B.G. Hospital, GB-4, 1st Floor, 57 Dr. S. C. Banerjee Road, Beliaghata, Kolkata, India
4Department of Medicine, Medical College Kolkata, 88 College Street, Kolkata, West Bengal, India
5Department of Community Medicine, A.I.I.H. & P.H., Kolkata, West Bengal, India

Received 31 May 2015; Accepted 4 August 2015

Academic Editor: Jay C. Brown

Copyright © 2015 Soumyabrata Nag et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Herpes simplex virus type 2 (HSV-2) is the cause of most genital herpes while HSV-1 is responsible for orolabial and facial lesions. In immunocompromised individuals, like HIV patients, impaired immunity leads to more frequent symptomatic and asymptomatic HSV infection. Fifty-two blood samples from HIV patients with clinically diagnosed HSV infection were taken as cases, while 45 blood samples each from HIV-infected (HIV control) and noninfected patients without any herpetic lesion (non-HIV control) were taken as control. Serum was tested for IgM and IgG antibodies of both HSV-1 and HSV-2 by ELISA. The seroprevalence was compared among the three groups of study population, considering the demographic and socioeconomic parameters. The HSV-2 IgM was significantly higher () in the HIV patient group (34.6%) than the HIV control (2.2%) and non-HIV control (2.2%) groups, whereas HSV-2 IgG seroprevalence was higher in both HIV patient (61.5%) and HIV control (57.8%) groups than the non-HIV control group (17.8%). The prevalence of HSV-2 was significantly higher in persons with multiple partners and in the reproductive age group. The overall seroprevalence of HSV-1 IgM was too low (<5%), whereas it was too high (about 90%) with HSV-1 IgG in all three study groups.