Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model

<table class="figure-group"><tr class="fig-image" id="a"><td><object data="https://static.hindawi.com/articles/av/volume-2016/8059607/figures/8059607.fig.002a.svgz" name="8059607.fig.002a" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(a) </b>Activated macrophage (MP) with phagosomes and polymorphous virus particles (Vpt) in the necrotic focus of the liver. Day 1 p/i</td></tr><tr class="fig-image" id="b"><td><object data="https://static.hindawi.com/articles/av/volume-2016/8059607/figures/8059607.fig.002b.svgz" name="8059607.fig.002b" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(b) </b>Necrotic focus in the liver, day 5 p/i. Arrows show the virus replication centers in the cell debris</td></tr><tr class="fig-image" id="c"><td><object data="https://static.hindawi.com/articles/av/volume-2016/8059607/figures/8059607.fig.002c.svgz" name="8059607.fig.002c" type="image/svg+xml"></object></td></tr><tr class="fig-caption"><td><b>(c) </b>Cell fragment with osmiophilic inclusions (arrows), virus particles (Vpt), and viroplasm (Vpl) in the nucleus. Day 7 p/i</td></tr></table>

<div>Wild-type EBOV nonlethal infection in guinea pigs. Electron microscopy of the liver.</div>

Advances in Virology

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Figure 2: Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model 