Adapted Lethality: What We Can Learn from Guinea Pig-Adapted Ebola Virus Infection Model

Figure 3

GPA-EBOV lethal infection in guinea pigs. Electron microscopy of the liver.

(a) Fragment of liver acinus. Arrow points to a sinus. Er: erythrocyte, Vpt: virus particle, T: thrombocyte, and H: hepatocyte

(b) Arrow shows virus particles (Vpt) in subendothelial space. Day 1 p/i

(c) Destroyed macrophage (MP) debris, fibrin deposits (arrow), virus particles (Vpt), and hepatocytes (H) in colliquative necrosis in the necrotic focus. Day 2 p/i

(d) Hepatocytes (H) in focal necrosis with their cytoplasm and perisinusoidal space filled with numerous virus particles (arrow). Day 2 p/i

(e) Fibrin deposit (arrow) in the necrotic focus. Day 5 p/i

(f) Kupffer cell (CC) in the perisinusoidal space. Cytoplasm contains phagosomes, virus particles (Vpt), viroplasm, and nucleocapsids. Day 5 p/i

(g) Large necrotic focus in the liver with virus particles (Vpt) found ubiquitously. Day 7 p/i

(h) Necrotic macrophage with cytoplasm containing viroplasm (Vpl), nucleocapsids, and phagosomes. Day 7 p/i

(i) Hepatocyte containing viroplasm (Vpl) and virus particles (Vpt). Day 7 p/i