Research Article
HBV Core Promoter Inhibition by Tubulin Polymerization Inhibitor (SRI-32007)
Table 1
Activity of SRI-32007 in the HBV virus yield assay in HepG2.2.2.15 cells.
| | Compound | HBV virus yield assay | HBe Ag in culture supernatant | | EC50 (nM) | CC50 (nM) | Selectivity index (CC50/EC50) | EC50 (nM) | CC50 (nM) | Selectivity index (CC50/EC50) |
| | SRI-32007 | 60.1 | 433 | 7.2 | 80 | 433 | 5.4 | | Lamivudine/3 TC | 20 | >2000 | >100 | >2000 | >2000 | >1 |
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