Comparative Performance Evaluation of FilmArray BioFire RP2.1 and MAScIR 2.0 Assays for SARS-CoV-2 Detection

Table 4

Performance evaluation of FilmArray RP2.1 for SARS-CoV-2 detection in other series compared with our own [11–14].

Authors	Sample size		Comparative assay		FilmArray RP2.1 performance
	Positive	Negative	NAAT	Targets	PPV [%]	NPV [%]	Sensitivity [%]	Specificity [%]
Eckbo et al. [11]	25	5	LDT	RdRp and E	100	100	100	100
Creager et al. [12]	50	50	Hologic panther fusion SARS-CoV-2 (15 samples)	ORF1ab	100	98	97.9	100
			LDT (15 samples)	N1 and N2
			Roche cobas SARS-CoV-2 (20 samples)	ORF1a and E
Johnson et al. [13]	16	17	GeneXpert xpert xpress SARS-CoV-2/Flu/RSV	E and N2	100	100	100	100
Jian et al. [14]	125 (50 wild-type SARS-CoV-2 specimens and 75 SARS-CoV-2 alpha variant specimens)	200	LDT	ORF1ab and E	100	99.5	99.2	100
Tazi et al. (our series)	80	80	MAScIR SARS-CoV-2 M kit 2.0	RdRp and S	73.8	100	100	79.2

E: envelope gene; LDT: laboratory-developed test; N: nucleocapsid gene; NPV: negative predictive value; ORF: open reading frame; PPV: positive predictive value; RdRp: RNA-dependent RNA polymerase gene; S: spike gene.