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Bioinorganic Chemistry and Applications
Volume 3, Issue 3-4, Pages 317-329
http://dx.doi.org/10.1155/BCA.2005.317

Structural Features of Antitumor Titanium Agents and Related Compounds

1Instituto di Chimica Biomolecolare, CNR, Piazzale Aldo Moro, 5, Rome 00185, Italy
2Vassar College, Department of Chemistry, Poughkeepsie 12604-0484, NY, USA
3Vassar College, SCIVIS laboratory, Poughkeepsie 12604-0724, NY, USA
4Università di Camerino, Facoltà di Scienze Chimiche, Via S. Agostino 1, Camerino (MC), Italy

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Previous studies established some Ti compounds as having marked activity against tumors of the gastrointestinal tract and lack of side effects common to widely used cytostatic agents. We describe pertinent structural features of known antitumor Ti agents and other potentially active compounds. Particularly noteworthy features are that Ti-O bonds are short and Ti-O-Ti bond angles are large, demonstrating that in these compounds the O binding has high s-character approaching sp hybridization.