Abstract
In order to develop platinum complexes with selective activity in primary and secondary bone
malignancies and with the aim to optimize antitumor activity, platinum(II) complexes with
aminotris(methylenephosphonic acid) as bone-seeking (osteotropic) ligand have been synthesized,
characterized and tested in the cisplatin-sensitive ovarian carcinoma cell line CH1. As non-leaving diamine
ligands, which are decisive for the cellular processing of DNA adducts, cis-R,S-cyclohexane-1,2-diamine,
trans-S,S-cyclohexane-1,2-diamine and trans-R,R-cyclohexane-1,2-diamine have been used, resulting in
complexes 1, 2, and 3, respectively. The cytotoxicity of the complexes under investigation decreases in the
order 3