Kinetic Study of DNA Modification by Phthalocyanine Derivative of the Oligonucleotide

Kuznetsova, Alexandra A.; Chernonosov, Alexander A.; Kuznetsov, Nikita A.; Koval, Vladimir V.; Knorre, Dmitri G.; Fedorova, Olga S.

doi:https://doi.org/10.1155/BCA/2006/23560

Bioinorganic Chemistry and Applications

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Volume 2006 | Article ID 023560 | https://doi.org/10.1155/BCA/2006/23560

Kinetic Study of DNA Modification by Phthalocyanine Derivative of the Oligonucleotide

Alexandra A. Kuznetsova,^1,2Alexander A. Chernonosov,^1,3Nikita A. Kuznetsov,^1,2Vladimir V. Koval,^1,2Dmitri G. Knorre,¹and Olga S. Fedorova^1,2

Received14 May 2006

Revised26 Jul 2006

Accepted13 Sept 2006

Published14 Dec 2006

Abstract

Design of chemically modified oligonucleotides for regulation of gene expression has attracted considerable attention over the last decades. One actively pursued approach involves antisense or antigene constructs carrying reactive groups, many of these based on transition metal complexes. The complexes of Co(II) with phthalocyanines are extremely good catalysts of oxidation of organic compounds with molecular oxygen and hydrogen peroxide. In this study, we have investigated the kinetics and thermodynamics of sequence-specific modification of DNA with deoxyribooligonucleotide linked to Co(II)-tetracarboxyphthalocyanine (PtcCo(II)) in the presence of H2O2.

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Copyright

Copyright © 2006 Alexandra A. Kuznetsova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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