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Bioinorganic Chemistry and Applications
Volume 2006 (2006), Article ID 59509, 10 pages
http://dx.doi.org/10.1155/BCA/2006/59509

Synthesis, Spectral, and Biological Properties of Copper(II) Complexes of Thiosemicarbazones of Schiff Bases Derived from 4-Aminoantipyrine and Aromatic Aldehydes

1Department of Chemistry, School of Pure and Applied Sciences, University of the South Pacific, PO Box 1168, Suva, Fiji
2Department of Chemistry, Lajpat Rai Postgraduate College, Sahibabad 201005 (Ghaziahad), India

Received 9 February 2005; Revised 15 April 2005; Accepted 25 April 2005

Copyright © 2006 Ram K. Agarwal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have synthesized a novel series of Schiff bases by condensation of 4-aminoantipyrine and various aromatic aldehydes followed by reaction with thiosemicarbazide. These thiosemicarbazones are potential ligands toward transition metal ions. The reaction of copper(II) salts with 4[N-(benzalidene)amino]antipyrinethiosemicarbazone (BAAPTS), 4[N-(4-methoxybenzalidene) amino] antipyrinethiosemicarbozone (MBAAPTS), 4[N-(4-dimethylamino benzalidene) amino] antipyrinethiosemicarbazone (DABAAPTS), and 4[N-(cinnamalidene) amino] antipyrinethiosemicarbazone (CAAPTS) resulted in the formation of solid complexes with the general composition CuX2(H2O)(L)(X = Cl, Br, NO3, NCS, or CH3COO; L = BAAPTS, MBAAPTS, DABAAPTS, or CAAPTS). These complexes were characterized through elemental analysis, molecular weight, electrical conductance, infrared, electronic spectra, and magnetic susceptibilities at room temperature. Copper(II) complexes with BAAPTS and MBAAPTS were screened for antibacterial and antifungal properties and have exhibited potential activity. Thermal stabilities of two representative complexes were also investigated.