Bioinorganic Chemistry and Applications

Bioinorganic Chemistry and Applications / 2006 / Article

Open Access

Volume 2006 |Article ID 060291 | https://doi.org/10.1155/BCA/2006/60291

Sotiris K. Hadjikakou, Nick Hadjiliadis, "Interaction of Thioamides, Selenoamides, and Amides with Diiodine", Bioinorganic Chemistry and Applications, vol. 2006, Article ID 060291, 10 pages, 2006. https://doi.org/10.1155/BCA/2006/60291

Interaction of Thioamides, Selenoamides, and Amides with Diiodine

Received25 Jun 2006
Revised27 Aug 2006
Accepted08 Sep 2006
Published13 Dec 2006

Abstract

We review the results of our work on the iodine interaction with thioamides, selenoamides, and amides. Complexes with (i) “spoke” or “extended spoke” structures, DI2 and DI2I2, respectively, (D is the ligand donor) (ii) iodonium salts of {[D2I]+[In]} (n=3, 7) and {[D2I]+[FeCl4]} formulae and (iii) disulfides of the categories (a) [D-D], (b) {[D-DH]+[I3]} have been isolated and characterized. A compound of formula {[D2I]+[I3][DI2]} containing both types of complexes (i) and (ii) was also isolated. The interaction of diiodine with selenium analogs of the antithyroid drug 6-n-propyl-2-thiouracil (PTU), of formulae RSeU (6-alkyl-2-Selenouracil) results in the formation of complexes with formulae [(RSeU)I2]. All these results are correlated with the mechanism of action of antithyroid drugs. Finally, we review here our work on the diiodine interaction with the amides (LO).

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Copyright © 2006 Sotiris K. Hadjikakou and Nick Hadjiliadis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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