Interaction of Thioamides, Selenoamides, and Amides with Diiodine

Hadjikakou, Sotiris K.; Hadjiliadis, Nick

doi:https://doi.org/10.1155/BCA/2006/60291

Bioinorganic Chemistry and Applications

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Volume 2006 | Article ID 060291 | https://doi.org/10.1155/BCA/2006/60291

Interaction of Thioamides, Selenoamides, and Amides with Diiodine

Sotiris K. Hadjikakou¹and Nick Hadjiliadis¹

Received25 Jun 2006

Revised27 Aug 2006

Accepted08 Sept 2006

Published13 Dec 2006

Abstract

We review the results of our work on the iodine interaction with thioamides, selenoamides, and amides. Complexes with (i) “spoke” or “extended spoke” structures, D⋅I2 and D⋅I2⋅I2, respectively, (D is the ligand donor) (ii) iodonium salts of {[D2−I]+[In]−} (n=3, 7) and {[D2−I]+[FeCl4]−} formulae and (iii) disulfides of the categories (a) [D-D], (b) {[D-DH]+[I3]−} have been isolated and characterized. A compound of formula {[D2−I]+[I3]−[D⋅I2]} containing both types of complexes (i) and (ii) was also isolated. The interaction of diiodine with selenium analogs of the antithyroid drug 6-n-propyl-2-thiouracil (PTU), of formulae RSeU (6-alkyl-2-Selenouracil) results in the formation of complexes with formulae [(RSeU)I2]. All these results are correlated with the mechanism of action of antithyroid drugs. Finally, we review here our work on the diiodine interaction with the amides (LO).

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Copyright

Copyright © 2006 Sotiris K. Hadjikakou and Nick Hadjiliadis. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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